Sequence of mdr3 cDNA encoding a human P-glycoprotein
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Monomeric bile acids modulate the ATPase activity of detergent-solubilized ABCB4/MDR3
2021, Journal of Lipid ResearchStimulation of ABCB4/MDR3 ATPase activity requires an intact phosphatidylcholine lipid
2020, Journal of Lipid ResearchVariants in ABCB4 (MDR3) across the spectrum of cholestatic liver diseases in adults
2020, Journal of HepatologyCitation Excerpt :ABCB11 (ATP binding cassette subfamily B member 11) resides on chromosome 2 (2q31) and encodes the canalicular bile salt export pump (BSEP),11 the main transporter of bile acids from hepatocytes into bile. PFIC-3 is caused by variants in ABCB4 (ATP binding cassette subfamily B member 4) located on chromosome 7 (7q21) encoding the ABCB4 protein.12 Recently, further gene defects were detected in patients with PFIC (PFIC4: TJP2, PFIC5: FXR, PFIC6: MYO5B; Fig. 3).13–15
Sequencing of FIC1, BSEP and MDR3 in a large cohort of patients with cholestasis revealed a high number of different genetic variants
2017, Journal of HepatologyCitation Excerpt :BSEP excretes bile salts from the hepatocyte into the bile canaliculus, which represents the major driving force of bile salt-dependent bile flow.5–7 While the human ABCB11 gene is located on chromosome 2q24,8 the ABCB4 gene is positioned on chromosome 7q21.9 MDR3 acts as a floppase and transports lipids of the phosphatidylcholine family from the inner to the outer leaflet of the canalicular membrane.10–12
The transmission interfaces contribute asymmetrically to the assembly and activity of human P-glycoprotein
2015, Journal of Biological Chemistry