Free radicals in immunological killing: The case of tumour necrotising factor (TNF)

doi:10.1016/0306-9877(86)90019-8

Medical Hypotheses

Volume 21, Issue 3, November 1986, Pages 267-271

https://doi.org/10.1016/0306-9877(86)90019-8 Get rights and content

Abstract

There is now considerable evidence that in many circumstances free radical activity constitutes not only an early but also an essential event in the causation of cell death $in$ $vivo$ . It is proposed that the cytotoxic effect of TNF against tumours may be exerted in like manner, by stimulating the generation of hydroxyl radicals which leads in turn to an upset of energy metabolism, and hence to cell death. Simple experimental protocols are indicated for testing the proposal at various stages.

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Free radicals in immunological killing: The case of tumour necrotising factor (TNF)

Abstract

Lancet

Cancer Lett

FEBS Lett

FEBS Lett

Lactoferrin enhances hydroxyl radical production by human neutrophils, neutrophil particulate fractions, and an enzymatic generating system

J Clin Invest

Oxygen toxicity in eukaryotes

Biological defence mechanisms. The production by leucocytes of superoxide, a potential bactericidal agent