Muscle reinnervation—III. Motoneuron sprouting capacity, enhancement by exogenous gangliosides

doi:10.1016/0306-4522(83)90189-6

Neuroscience

Volume 8, Issue 3, March 1983, Pages 417-429

https://doi.org/10.1016/0306-4522(83)90189-6 Get rights and content

Abstract

Rat soleus muscle was partially denervated by resecting the L₅ mixed nerve. Muscle reinnervation was monitored 10, 30 and 50 days after surgery. The extent of recovery was found to be dependent on the number of axons remaining in the muscle and appeared not to be influenced by the time allowed. If animals were treated daily with 5 mg/kg of gangliosides the enlargement of the motor units was further enforced. The index of sprouting (expressed as the ratio between the percentage of muscle reinnervation due to a certain number of motor neurons in reinnervation and in normal conditions) was increased in a significant way by gangliosides treatment, i.e. one motor unit can expand up to about 4.5-fold, but if the animal was treated with gangliosides the motor unit can expand up to about 6.3-fold. These results showed that motoneuron sprouting capacity is increased by treatment animals with gangliosides.

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Citation Excerpt :
Such lesion causes a progressive atrophy of fast muscles, like the EDL, with a poor muscle reinnervation and severe loss of axotomized motor neurons [15]. EDL muscle reinnervation was evaluated by measuring isometric tension [13], muscle fibre innervation and size [11,14]. In addition, blood serum and muscle content of IGF-I, and blood serum levels of IGFBPs were assayed as previously described [15].
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Muscle reinnervation—III. Motoneuron sprouting capacity, enhancement by exogenous gangliosides

Abstract

Neuroscience

J. neurol. Sci.

Brain Res.

Expl Neurol.

Brain Res.

Exp. Cell Res.

Neuroscience

Recognition of cell types by axonal growth cones in vitro

Nature, Lond.

Growth cone formation in cultures of sensory neurones

A central role for denervated tissues in causing nerve sprouting

Nature, Lond.

Motor neuron sprouting induced by prolonged tetrodotoxin block of nerve action potential

Nature, Lond.

Polyneuronal innervation of skeletal muscle in new-born rats and its elimination during maturation

J. Physiol, Lond.

Partial denervation effects both denervated and innervated fibers in the mammalian skeletal muscle

Science, N.Y.

Effects of brain gangliosides on functional recovery in experimental regeneration and reinnervation

Properties of motor units in fast and slow skeletal muscles of the rat

J. Physiol., Lond.

Ganglioside and membrane receptors for cholera toxin

Biochemistry

The effect of gangliosides on the activity of adenylate cyclase and phosphodiesterase from rat cerebral cortex

Clustering of gangliosides in phospholipids bilayers

FEBS Lett.

Mechanisms of differentiation in cultured neurons: involvement of gangliosides

An electron-microscopic study of the changes induced by botulinum toxin in the motor end-plates of slow and fast skeletal muscle fibres of the mouse

J. Neurol. Sci.

The effect of botulinum toxin on the pattern of innervation of skeletal muscle in the mouse

Q. J. exp. Physiol.

Collateral nerve regeneration

Q. Rev. Biol.

The behaviour of residual axons in partially denervated muscles of the monkey

J. exp. Med.