Elsevier

Neuroscience Letters

Volume 199, Issue 2, 20 October 1995, Pages 95-98
Neuroscience Letters

Apolipoprotein E in sporadic and familial Creutzfeldt-Jakob disease

https://doi.org/10.1016/0304-3940(95)12030-8Get rights and content

Abstract

We assessed the apolipoprotein E (ApoE) genotype in 49 sporadic and ten familial Creutzfeldt-Jakob disease (CJD) patients, in seven healthy siblings with a PRNP mutation and in 84 controls. In sporadic CJD, ApoE genotypes and allelic frequencies do not significantly differ from that of controls. No influence of ApoE genotypes on age at onset was found. In familial cases, the disease appeared in mutated subjects showing the same ApoE genotype as members who have not yet developed CJD. Our results provide further evidence that ApoE is not a risk factor for CJD.

References (18)

There are more references available in the full text version of this article.

Cited by (32)

  • APOE gene polymorphisms and susceptibility to Creutzfeldt-Jakob disease

    2014, Journal of Clinical Neuroscience
    Citation Excerpt :

    There has been an obvious controversy in the research surrounding CJD that is due to differences in race, study design, selection criteria of patients, and sample sizes. While a significantly higher frequency of APOE 4 allele carriers in CJD patients has been reported compared to controls [28,33–35], other studies have found no significant differences in the APOE genotypes or the APOE 4 allele frequencies between CJD patients and controls [23,29–32]. APOE may be one candidate endogenous factor that affects the risk of developing CJD.

  • Apolipoprotein E in Alzheimer's disease and other neurological disorders

    2011, The Lancet Neurology
    Citation Excerpt :

    However, a contradictory report88 suggested that APOE ɛ4 was associated with definite or probable disease whereas APOE ɛ2 decreased disease-related mortality. Unlike several subsequent studies reporting no such association of APOE genotype in several ethnic populations,89–91 Amouyel and colleagues88 analysed the frequency of allele bearers rather than alleles and included patients with either familial or sporadic disease who were not age-matched with controls. Taken together, the studies suggest that APOE is associated with plaques in patients with Creutzfeldt-Jakob disease with no definite role in the disease process (table).

  • Increased frequency of positive family history of dementia in sporadic CJD

    2009, Neurobiology of Aging
    Citation Excerpt :

    An association between ApoE4 and CJD has been controversially discussed. While significantly higher frequency of ApoE4 allele carriers in CJD compared to controls was reported (Amouyel et al., 1994; Van Everbroeck et al., 1999), no significant difference of ApoE genotypes or ApoE4 allele frequency was found between CJD patients and controls in other studies (Nakagawa et al., 1995; Salvatore et al., 1995; Zerr et al., 1996). In contrast to the previous studies, we compared not only sCJD patients to controls, but also separately analyzed sCJD patients with and without PFH.

View all citing articles on Scopus

This work was partially supported by the National Registry of Creutzfeldt-Jakob disease, financed by the Italian Ministry of Health-Istituto Superiore di Sanità and by Italian National Research Council (CNR) Target Project on Aging (Grant no. 952608). BN was also supported by Telethon Italia (no. E.304).

1

We thank Prof. Giorgio Macchi and Dr. Maurizio Genuardi for helpful discussion and Ms. Deborah Wool for editorial assistance.

View full text