Apolipoprotein E in sporadic and familial Creutzfeldt-Jakob disease☆
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Cited by (32)
APOE gene polymorphisms and susceptibility to Creutzfeldt-Jakob disease
2014, Journal of Clinical NeuroscienceCitation Excerpt :There has been an obvious controversy in the research surrounding CJD that is due to differences in race, study design, selection criteria of patients, and sample sizes. While a significantly higher frequency of APOE 4 allele carriers in CJD patients has been reported compared to controls [28,33–35], other studies have found no significant differences in the APOE genotypes or the APOE 4 allele frequencies between CJD patients and controls [23,29–32]. APOE may be one candidate endogenous factor that affects the risk of developing CJD.
Apolipoprotein E in Alzheimer's disease and other neurological disorders
2011, The Lancet NeurologyCitation Excerpt :However, a contradictory report88 suggested that APOE ɛ4 was associated with definite or probable disease whereas APOE ɛ2 decreased disease-related mortality. Unlike several subsequent studies reporting no such association of APOE genotype in several ethnic populations,89–91 Amouyel and colleagues88 analysed the frequency of allele bearers rather than alleles and included patients with either familial or sporadic disease who were not age-matched with controls. Taken together, the studies suggest that APOE is associated with plaques in patients with Creutzfeldt-Jakob disease with no definite role in the disease process (table).
Increased frequency of positive family history of dementia in sporadic CJD
2009, Neurobiology of AgingCitation Excerpt :An association between ApoE4 and CJD has been controversially discussed. While significantly higher frequency of ApoE4 allele carriers in CJD compared to controls was reported (Amouyel et al., 1994; Van Everbroeck et al., 1999), no significant difference of ApoE genotypes or ApoE4 allele frequency was found between CJD patients and controls in other studies (Nakagawa et al., 1995; Salvatore et al., 1995; Zerr et al., 1996). In contrast to the previous studies, we compared not only sCJD patients to controls, but also separately analyzed sCJD patients with and without PFH.
Apolipoprotein E ε4 allele and Japanese late-onset depressive disorders
1999, Biological PsychiatryThe neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease
1998, Brain Research ReviewsNo implication of apolipoprotein E polymorphism in Italian schizophrenic patients
1998, Neuroscience Letters
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This work was partially supported by the National Registry of Creutzfeldt-Jakob disease, financed by the Italian Ministry of Health-Istituto Superiore di Sanità and by Italian National Research Council (CNR) Target Project on Aging (Grant no. 952608). BN was also supported by Telethon Italia (no. E.304).
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We thank Prof. Giorgio Macchi and Dr. Maurizio Genuardi for helpful discussion and Ms. Deborah Wool for editorial assistance.