Calcitonin gene-related peptide (human α-CGRP) counteracts vasoconstriction in human subarachnoid haemorrhage
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Calcitonin gene-related peptide and neurologic injury: An emerging target for headache management
2022, Clinical Neurology and NeurosurgeryFremanezumab inhibits vasodilatory effects of CGRP and capsaicin in rat cerebral artery - Potential role in conditions of severe vasoconstriction
2019, European Journal of PharmacologyCitation Excerpt :The physiology of CGRP is a double-edged sword. On one side CGRP plays a detrimental pathophysiological role in migraine via the trigeminovascular system and on the other side endogenous perivascular CGRP protects organs during states of severe vasoconstriction, e. g. subarachnoid hemorrhage (SAH) (Juul et al., 1990; Juul et al., 1994) or acute myocardial infarct (AMI) (Mair et al., 1990; Huang et al., 2008). Consequently, the CGRP-antagonistic antibodies might challenge endogenous neurovasular protection during local protection from severe vasoconstriction.
Vascular pathology of large cerebral arteries in experimental subarachnoid hemorrhage: Vasoconstriction, functional CGRP depletion and maintained CGRP sensitivity
2019, European Journal of PharmacologyCitation Excerpt :CGRP is a powerful endothelium-independent vasodilator located in sensory nerves innervating the cerebral circulation (Eftekhari and Edvinsson, 2010). The role of CGRP in SAH-induced vasoconstriction is not fully characterized, yet CGRP is released from perivascular sensory nerves potentially as a reflex response to prolonged SAH-induced vasoconstriction (Juul et al., 1994). However, eventually the perivascular CGRP stores might be functionally depleted and the vasodilatory counterbalance to SAH-induced vasospasm inefficient.
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