Toxicity-distribution relationships among 3-alkylfurans in the mouse lung☆
References (20)
- et al.
Distribution, excretion, and binding of radioactivity in the rat after intraperitoneal administration of the lung-toxic furan, ipomeanol
Toxicol. Appl. Pharmacol.
(1975) Studies on the activation of a model furan compound — Toxicity and covalent binding of 2(N-ethylcarbomaylhydroxymethyl)furan
Biochem. Pharmacol.
(1977)- et al.
Toxicity of butylated hydroxytoluene in mouse following oral administration
Toxicology
(1978) - et al.
Pulmonary bronchiolar alkylation and necrosis by 3-methylfuran, a naturally occurring atmospheric pollutant
Nature
(1978) - et al.
Perilla ketone: A potent lung toxin from the mint plant, Perilla frutesceus britton
Science
(1977) - et al.
The toxicity of two synthetic 3-substituted furan carbamates
Experentia
(1973) - et al.
Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes, including furossemide and cephaloridine
Toxicol. Appl. Pharmacol.
(1977) Biochemical mechanisms in pulmonary toxicity of furan derivatives
- W.M. Haschek, M.R. Boyd, P.J. Hakkinen, C.S. Owenby and H.P. Witschi, Acute inhalation toxicity of 3-methylfuran in the...
- et al.
Hepatic necrosis caused by furosemide
Nature
(1974)
Cited by (14)
A 90-day subchronic gavage toxicity study in Fischer 344 rats with 3-methylfuran
2018, Food and Chemical ToxicologyCitation Excerpt :Until recently, little attention had been paid to the effects and presence of methylfurans in foods until 2-methylfuran and 3-methylfuran were identified to be potent hepatotoxins (Wiley et al., 1984; Ravindranath et al., 1984; Ravindranath and Boyd, 1991). Little toxicological information was available for 3-methylfuran and in most of the available studies, the route of administration was by inhalation (Haschek et al., 1983;1984; Morse et al., 1984; Gammal et al., 1984) or intraperitoneal injection. With inhalation studies, furan, 2-methylfuran and 3-methylfuran were found to induce pulmonary, nasal and kidney toxicity (Gammal et al., 1984; Haschek et al., 1983;1984; Morse et al., 1984; Ravindranath et al., 1984; Witschi et al., 1985).
Heat-Generated Toxicants in Foods (Acrylamide, MCPD Esters, Glycidyl Esters, Furan, and Related Compounds)
2017, Chemical Contaminants and Residues in Food: Second EditionA 28-day gavage toxicity study in fischer 344 Rats with 3-methylfuran
2015, Toxicologic Pathology
- ☆
Presented at the 21st Annual Meeting, Society of Toxicology, Boston, MA 1982.