Synthesis and X-ray structural characterization of an iron(III) complex of the fluoroquinolone antimicrobial ciprofloxacin, [Fe(CIP)(NTA)]3·5H2O (NTANitrilotriacetato)
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2014, Bioorganic and Medicinal ChemistryBiomass against emerging pollution in wastewater: Ability of cork for the removal of ofloxacin from aqueous solutions at different pH
2013, Journal of Environmental Chemical EngineeringCitation Excerpt :The three protonation equilibria are completely defined by the relative constants K1 = [LH]/([L−][H+]), K2 = [LH2+]/([LH][H+]), and K3 = [LH32+]/([LH2+][H+]). There is a general agreement in attributing protonation steps to different groups in the molecules: K1 and K2 concerning the protonation of N4′ in the piperazine ring and of carboxylic group, respectively, while the protonation at high acid conditions is attributed to the 4-oxo group, also in accord to 13C NMR results [27]. The protonation sequence N4′ → COOH → CO is remarked by X-Ray structure of compounds LH, LH2+ and LH32+ [28–30].
Infrared multiple photon dissociation spectroscopy of ciprofloxacin: Investigation of the protonation site
2012, Chemical PhysicsCitation Excerpt :The important role of metal ions in the mechanism of action of these drugs is documented in a large number of studies [6,7]. There were numerous attempts to establish the character of the structure of ciprofloxacin [8,9] and its complexes with metal cations [10,11] using various methods including electrochemistry, X-ray diffraction and UV, IR and 1H NMR spectroscopies. These studies have shown that CIP is an amphoteric drug, with four possible species present in aqueous solution: cationic, non-ionic, zwitterionic and anionic, depending on the pH. The zwitterionic species predominates near physiological pH [12].
Nickel complexes of the different quinolone antibacterial drugs: Synthesis, structure and interaction with DNA
2012, Inorganica Chimica ActaCitation Excerpt :As is well known, the quinolones can act as not only antibacterial drugs, but also excellent multi-dentate ligands coordinating with metal ions by the oxygen and nitrogen atoms. In the literature, the structures of metal and rare earth ions complexes of diverse quinolones have been reported [11–16], and the results suggest that metal ion coordination might be involved in the antibacterial activity of drug molecules and improve the drugs activity. However a thorough survey of the literature has revealed that the single crystal structures of only Ag(I), Cu(II), Zn(II), Mg(II), Pd(II), VO(II), Cd(II), Fe(III), Bi(III) quinolones complexes have been characterized to date [17–23].