Low hepatic 7-ethoxyresorufin-O-deethylase (EROD) activity and minor alterations in retinoid and thyroid hormone levels in flounder (Platichthys flesus) exposed to the polychlorinated biphenyl (PCB) mixture, Clophen A50
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Cited by (31)
Effects of environmental chemicals on fish thyroid function: Implications for fisheries and aquaculture in Australia
2017, General and Comparative EndocrinologyCitation Excerpt :Table 1, section 1.2 summarises some effects of PCBs on the fish thyroid system with reference to congeners used, targeted fish species, exposure route, exposure period, exposure concentrations and main findings. Exposure of PCB congeners (Aroclor 1254, Clophen A50, PCB 77, PCB 126) caused increases in TH in fish, for example, Aroclor 1254 increased plasma T3 levels in coho salmon (Oncorhynchus kisutch) (Folmar et al., 1982) and Clophen A50 in flounder (Platichthys flesus) respectively (Besselink et al., 1996). The PCB congeners that increased T4 levels in fish were PCB 126 in lake trout (S. namaycush) (Brown et al., 2004b) and Clophen A50 in flounder (P. flesus) (Besselink et al., 1996).
Relative developmental toxicity of short-chain chlorinated paraffins in Zebrafish (Danio rerio) embryos
2016, Environmental PollutionCitation Excerpt :Wyatt et al. (1993) reported that SCCPs decreased TT4 levels in rat after a 14-day exposure at 1 g/kg. Decreasing T3 and/or T4 were generally reported in fish and mammals exposed to other chlorinated organic compounds, such as 2,3,7,8-tetrachlorodibenzodioxin (TCDD), polychlorinated dibenzofurans (PCDFs), Mirex, dichlorophenoxyacetic acid, and PCBs (Besselink et al., 1996; Bosveld et al., 2000; Brown et al., 2002; Charles et al., 1996; Gregory and Cyr, 2003; Leatherland and Sonstegard, 1979). For example, PCB in the form of Aroclor 1254 (0.2 and 1 mg/kg body mass/day) was reported to decrease plasma T3 without significantly altering T4 levels in Atlantic croaker via dietary exposure, while both T4 and T3 were decreased by PCB 153 (0.1 and 1 mg/kg/body mass/day) in the same study (LeRoy et al., 2006).
The Toxicity of Persistent Organic Pollutants to Aquatic Organisms
2015, Comprehensive Analytical ChemistryCitation Excerpt :Life-cycle testing with D. rerio adults exposed through the dietary route has demonstrated considerable bioaccumulation of PCBs in males and females, as well as maternal transfer to the eggs followed by a significant reduction in fecundity [35]. Further evidence of PCB-induced thyroid system disruption in fish has been reported in studies with sculpin [36], coho salmon (O. kisutch) [37,38], rainbow trout (O. mykiss) [37,39], European flounder (Platichthys flesus) [40], and white suckers (Catostomus commersoni) [41]. Early-life-stage effects in fish species other than D. rerio have been reported in testing with eggs taken from lake trout (S. namaycush), where significant relationships were observed between embryonic mortality (eggs dying between fertilization and hatch) and the concentrations of total PCBs in both the eggs and adults [42].
Toxicological effects of clofibric acid and diclofenac on plasma thyroid hormones of an Indian major carp, Cirrhinus mrigala during short and long-term exposures
2014, Environmental Toxicology and PharmacologyCitation Excerpt :T3 is the active form of THs and it is largely produced by the peripheral enzymatic monodeiodination of T4 mainly in the liver and other tissues (Van der Geyten et al., 1998). Most of the chemical compounds such as polychlorinated biphenyls and pesticides can lead to increase of T3 in blood by altering 5′-deiodinase activity in fish (Besselink et al., 1996; Adams et al., 2000; Coimbra et al., 2005; Picard-Aitken et al., 2007; Peter et al., 2009; Yu et al., 2011; Guo and Zhou, 2013; Yu et al., 2013). In this study, the observed increase in plasma T3 level may be a response to maintenance of the basal metabolic rate of the fish to ensure its survival.