Long-circulating iron oxides for MR imaging

https://doi.org/10.1016/0169-409X(95)00033-4Get rights and content

Abstract

A variety of iron oxide preparations with long blood half-lives have been synthesized for MR imaging. Potential applications of these agents include MR angiography, RES imaging, target specific imaging and neuronal transport imaging. This chapter reviews types of iron oxide and mechanisms that are responsible for a prolonged plasma half-life.

References (50)

  • H.H. Bengele et al.

    Biodistribution of an ultrasmall superparamagnetic iron oxide colloid, BMS 180549, by different routes of administration

    Magn. Reson. Imaging

    (1994)
  • R. Weissleder et al.

    Pharmaceutical iron oxides for MR imaging

    Rev. Magn. Reson. Med.

    (1993)
  • K. Widder et al.

    Magnetic microspheres: a model system for site specific drug delivery in vivo

  • T. Kato et al.

    Magnetic microcapsules for targeted delivery of anticancer drugs

    Appl. Biochem. Biotechnol.

    (1984)
  • G.L. Wolf et al.

    Contrast agents for magnetic resonance imaging

  • M. Mendonca-Dias et al.

    Ferromagnetic particles as contrast agents for magnetic resonance imaging of the liver and spleen

    Magn. Reson. Med.

    (1986)
  • D.J. Widder et al.

    Magnetite albumin microspheres: a new MR contrast material

    Am. J. Roentgenol.

    (1987)
  • P.F. Renshaw et al.

    Ferromagnetic contrast agents: a new approach

    Magn. Res. Med.

    (1986)
  • P.F. Renshaw et al.

    Ferromagnetic antibody relaxation technique

  • G.C. Bacic et al.

    The use of dextran-magnetite for liver enhancement

  • A. Hemmingson et al.

    Relaxation enhancement of the dog liver and spleen by biodegradable superparamagnetic particles in proton magnetic resonance imaging

    Acta Radiol.

    (1987)
  • S. Saini et al.

    Ferrite particles: a superparamagnetic MR contrast agent for the reticuloendothelial system

    Radiology

    (1987)
  • M. Papisov et al.

    Target specific nuclear magnetic resonance imaging with antibody-iron-oxide particles

  • R. Maas et al.

    Ultrasmall magnetic particles coated with polyethyleneglycol as contrast agent in MRI of experimental abscesses: an animal study in mini-pigs

  • R. Weissleder et al.

    Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging

    Radiology

    (1990)
  • Cited by (385)

    • Functionalized magnetic nanoparticles for treating bone diseases

      2023, Nanomedicine: Technologies and Applications
    • Biochemical changes of macrophages and U87MG cells occurring as a result of the exposure to iron oxide nanoparticles detected with the Raman microspectroscopy

      2022, Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
      Citation Excerpt :

      However, the mechanism of this process was probably different for macrophages and glioma cells. In the case of macrophages the internalization probably occurred through the phagocytosis, which for these cells is the most efficient way for endocytosis of particles with size 50–180 nm [41,42]. Therefore, IONPs with a 30 nm core size and a 87 nm hydrodynamic diameter, were possibly phagocytized by macrophages and after decomposition in the acidic environment of their lysosomes the residual Fe was built into aforementioned adducts [43].

    • Magnetic systems for cancer immunotherapy

      2021, Acta Pharmaceutica Sinica B
    View all citing articles on Scopus
    View full text