Phase transition temperature reduction and glass formation in dehydroprotected lyophilized liposomes
References (35)
Cryomicroscopy of liposome systems as simple models to study cellular freezing response
Cryobiology
(1984)- et al.
Mechanisms of intracellular ice formation
Biophys. J.
(1990) - et al.
Interactions of sugars with membranes
Biochim. Biophys. Acta
(1988) - et al.
Trehalose and dry dipalmitoylphosphatidylcholine revisited
Biochim. Biophys. Acta
(1988) - et al.
Effect of trehalose on the phase properties of hydrated and lyophilized dipalmitoylphosphatidylcholine multilayers
Cryobiology
(1989) - et al.
The interactions of saccharides with lipid bilayer vesicles: stabilization during freeze-drying and freeze-thawing
Biochim. Biophys. Acta
(1986) - et al.
Interaction of carbohydrates with dry dipalmitoylphosphatidylcholine
Arch. Biochem. Biophys.
(1985) - et al.
Prevention of fusion and leakage in freeze dried liposomes by carbohydrates
Biochim. Biophys. Acta
(1986) - et al.
Preservation of freeze-dried liposomes by trehalose
Arch. Biochem. Biophys.
(1985) - et al.
Small-volume extrusion apparatus for preparation of large, unilamellar vesicles
Biochim. Biophys. Acta
(1991)
Calorimetric determination of phospholipids with ammonium ferrothiocyanate
Anal. Bioch.
High-pressure infrared spectroscopic evidence of water binding sites in 1,2-diacyl phospholipids
Chem. Phys. Lipids
Hydration of phosphatidylcholine reverse micelles and multilayers: an infrared spectroscopic study
Chem. Phys. Lipids
Critical parameters in the freezing of liposomes
Int. J. Pharmaceut.
Solute-water interactions: do polyhydroxycompounds alter the properties of water?
Cryobiology
Water, temperature and life
Phil. Trans. R. Soc. London B
Cold-induced lipid phase transitions
Phil. Trans. R. Soc. London B
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Low temperature, easy scaling up method for development of smart nanostructure hybrid lipid capsules for drug delivery application
2020, Colloids and Surfaces B: BiointerfacesCitation Excerpt :However, lyophilization without trehalose results in drastic reduction of particle size indicating possible destruction of nHLCs structure during lyophilization. The little change in size of lyophilized nHLCs with optimum trehalose composition (≥10 %) upon rehydration (smaller than non-lyophilized) may be due to possible interaction of sugar molecules with molecules of nHLCs membrane as well as forming surrounding glassy-matrix [39]. Fig. SI-3 shows the camera images of the non-lyophilized nHLCs, lyophilized powder and rehydrated lyophilized suspension of nHLCs.
Evaluation of various tissue-clearing techniques for the three-dimensional visualization of liposome distribution in mouse lungs at the alveolar scale
2019, International Journal of PharmaceuticsCitation Excerpt :Liposomes are believed to be disrupted by surface-active agents in a concentration-dependent manner (Domecq et al., 2001; Petralito et al., 2014). In this study, because our liposomes were composed of HEPC with a high phase transition temperature (52 °C) (Mobley and Schreier, 1994), the liposomes have high stability and low pre-leakage of the encapsulated drugs. In addition, encapsulated FITC-dextran has low permeability through liposomal membranes based on its high molecular weight (10 kDa).