Synthesis of albumin-dextran sulfate microspheres possessing favourable loading and release characteristics for the anticancer drug doxorubicin☆
References (14)
- et al.
Biophysical drug targeting: magnetically responsive albumin microspheres
Methods Enzymol.
(1985) - et al.
Albumin-heparin microspheres as carriers for cytostatic agents
J. Controlled Release
(1990) - et al.
In vitro release of cytotoxic agents from ion exchange resins
J. Controlled Release
(1989) - et al.
Hydrophilic albumin microspheres
Methods Enzymol.
(1985) - et al.
Influence of stabilisation temperature on the entrapment of adriamycin in albumin microspheres
Drug. Dev. Ind. Pharm.
(1987) - et al.
Cytotoxic-loaded albumin microspheres: a novel approach to regional chemotherapy
Br. J. Surg.
(1988) - et al.
Albumin microspheres as vehicles for the sustained and controlled release of doxorubicin
J. Pharm. Pharmacol.
(1989)
Cited by (46)
Enhancement of the efficacy of synthetic and natural anticancer agents through nanocarrier for colon cancer treatment
2024, European Journal of Medicinal Chemistry ReportsProtein and peptide delivery through glycogen and dextran
2023, Peptide and Protein Drug Delivery Using PolysaccharidesLipid-polymer nano core-shell type hybrid system for colon specific drug delivery
2021, Journal of Drug Delivery Science and TechnologyCitation Excerpt :Solid lipid nanoparticulate systems (SLNPs) are advanced nano lipid carrier systems in addition to the traditional ones such as liposomes, lipid emulsions, and polymeric nanoparticles [22]. SLNPs have adequate tolerability, scaling-up utility, ability to integrate hydrophobic or hydrophilic drugs, and have an enriched stability of encapsulated drugs [22–30]. The aim of the current work is to formulate, optimize and characterize (using both in vitro and in vivo studies) mesalamine loaded solid lipid drug delivery systems to address formulation and treatment related issues in oral delivery by developing controlled SLNP drug delivery systems.
Potential of Cationic-Polymeric Nanoparticles for Oral Delivery of Naringenin: In Vitro and In Vivo Investigations
2018, Journal of Pharmaceutical SciencesCitation Excerpt :The %EE and %DL depend on drug solubility in the excipients matrix material (solid polymer or liquid dispersion agent), which is related to the matrix composition, molecular weight, drug-polymer interactions, and the presence of end functional groups in either the drug or matrix.49-51 For small molecules like NRG, studies show the use of ionic interaction between the drug and matrix materials can be very effective in increasing %EE and %DL.52,53 The surface morphology of optimized NRG-EE100-NPs was determined by HR-TEM micrographs.
Recent advances in nanoparticle-mediated drug delivery
2017, Journal of Drug Delivery Science and TechnologyCitation Excerpt :The macromolecule displays greatest loading efficiency when it is loaded at or near its isoelectric point where it has lower solubility and high adsorption. For the molecules smaller in size, studies demonstrate the role of ionic interaction between the drug and matrix materials can be a very effective way to increase the drug loading [60]. To develop a successful nano-drug carrier system, both drug expulsion and polymer biodegradation are importantly considered.
Strategies for targeted drug delivery in treatment of colon cancer: current trends and future perspectives
2017, Drug Discovery TodayCitation Excerpt :For drug targeting, nanocarrier surface chemistry plays an important part in improving the circulation time of nanocarriers in blood. During the past decade, a great deal of surface modification has been attempted to develop the so-called ‘stealth’ particles or PEGylated NPs, which can escape from macrophages or phagocytes [12]. A variety of nanosystems including synthetic biodegradable polymers, such as chitosan (CS), polycaprolactone (PCL) or poly-lactic-co-glycolic acid (PLGA), lipids (liposomes, nano-liposomes, solid-lipid NPs), and other nanosystems including mesoporous silica NPs (MSNs), micelles, quantum dots (QDs), carbon nanotubes (CNTs) [13] and iron oxide magnetic nanoparticles (MNPs) have been investigated.
- ☆
A provisional patent on this work has been lodged in Australia (PM2492).