Nanoparticles as carriers for growth hormone releasing factor
References (16)
- et al.
Glucose-sensitive membranes for controlled delivery of insulin: insulin transport studies
J. Controlled Release
(1985) - et al.
Effects of sodium taurodihydrofusidate on nasal absorption of insulin in sheep
J. Pharm. Sci.
(1987) - et al.
Hypoglycemic effect of liposome-entrapped insulin administered intragastrically into rats
Lancet
(1976) - et al.
Oral ingestion of insulin liposomes: effects of the administration route
Life Sci.
(1981) - et al.
Degradation of poly(isobutyl cyanoacrylate) nanoparticles
Biomaterials
(1984) - et al.
Self-regulating insulin delivery systems. Part 1. Synthesis and characterization of glycosylated insulin
J. Controlled Release
(1984) - et al.
Nasal absorption of insulin: enhancement by hydrophobic bile salts
- et al.
Systemic and oral administration of liposomes
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The delivery of drugs - peptides and proteins
2019, Comprehensive BiotechnologyAdvances on the formulation of proteins using nanotechnologies
2017, Journal of Drug Delivery Science and TechnologyCitation Excerpt :Due to their rapid and easy polymerization, alkylcyanoacrylates have been the monomers of choice for this purpose [133,134]. Unfortunately, the potential reaction between the drug and the reactive monomers during the process constitutes a limitation of this approach [135]. Interfacial polymerization in oily core nanocapsules.
Mucoadhesive properties of low molecular weight chitosan- or glycol chitosan- and corresponding thiomer-coated poly(isobutylcyanoacrylate) core-shell nanoparticles
2017, European Journal of Pharmaceutics and BiopharmaceuticsCitation Excerpt :In these cases, inhibition of the P-gp generally enhances drug absorption as reported considering important anticancer agents such as Paclitaxel [19]. In previous studies, it has been shown that poly(alkylcyanoacrylate) (PACA) nanoparticles (NPs) are able to encapsulate peptides, proteins [20–23] and anticancer agents [19]. However, due to the hydrophobic character of PACA as well as to the negative charge of the surface of the corresponding NPs, their mucoadhesive potential is generally low and therefore they are of limited usefulness for transmucosal delivery.
The application of MALDI TOF MS in biopharmaceutical research
2011, International Journal of PharmaceuticsCitation Excerpt :Thus, the formulation of small histidine-containing peptides, such as d-Lys6-GnRH, into PACA nanoparticles is an example for a pharmaceutical formulation with limited perspective to enter the biopharmaceutical market for human therapeutics. Polymer systems, including PACA nanoparticles, have also been deliberately conjugated to protein and peptide bioactives for reasons of enhanced entrapment efficiency (Liang et al., 2008), modified/sustained release characteristics (Grangier et al., 1991; Singh et al., 2007), targeted release (Pasut and Veronese, 2007), improved stability (Hillery et al., 1996; Pasut and Veronese, 2007), prolonged biological half lives (Pasut and Veronese, 2007) and enhanced absorption (Veronese and Harris, 2008). This approach, however, requires the site-specific functionalization of either protein/peptide or polymer in order to produce hybrid constructs with well-defined protein/peptide segments and well defined polymer chains (Gauthier and Klok, 2008).
The Delivery of Drugs - Peptides and Proteins
2011, Comprehensive Biotechnology, Second EditionRelease and bioactivity of PACA nanoparticles containing D-Lys <sup>6</sup>-GnRH for brushtail possum fertility control
2011, Journal of Controlled ReleaseCitation Excerpt :Previously, we have demonstrated the covalent interference of some protein and peptide drugs, including D-Lys6-GnRH, during the polymerization process, which may explain the low release of bioactive observed in some studies [19,20]. The sustained release of bioactive via the bioerosion of the polymer material has previously been suggested for peptide copolymerized PACA nanoparticles in the presence of esterases and rat plasma [21]. Whether or not peptide released from copolymerized PACA nanoparticles is still bioactive has been investigated only in a few studies.