The release of prostaglandin E2 from a novel crystalline-rubbery poly (ethylene oxide) network crosslinked by 3,4-dihydro-2H-pyranyl-2-methyl-(3,4-dihydro-2H-pyran-2-carboxylate)

doi:10.1016/0168-3659(85)90048-3

Journal of Controlled Release

Volume 2, November 1985, Pages 231-244

https://doi.org/10.1016/0168-3659(85)90048-3 Get rights and content

Abstract

The synthesis and aqueous swelling properties of a new family of crystalline-rubbery hydrogels based on poly (ethylene glycols) (PEG) and 3,4-dihydro-2H-pyranyl-2-methyl-(3,4-dihydro-2H-pyran-2-carboxylate) are described. Their use as monolithic delivery systems for prostaglandin E₂ (PGE₂) is presented and compared with the delivery of PGE₂ from urethane crystalline-rubbery poly (ethylene oxide) (PEO) hydrogels of similar crystal-linity and swelling. The fractional-release/time plots for PGE₂ from devices of identical geometry and drug loading, but based on the two different crosslinking structures were essentially superimposable.

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Cited by (5)

A study of controlled-release systems for progesterone based on crosslinked poly(ethylene oxides)
1993, International Journal of Pharmaceutics
The characteristics of suspension-type matrices for the controlled release of hydrophobic drugs, based on crosslinked poly(ethylene oxides) (cr-PEO) have been investigated using progesterone (PGT) as a model drug. The drug amounts that can be reproducibly loaded in polymer by an impregnation technique are limited by crystalline drug expulsion from the matrix during solvent evaporation, depending on the degree of crosslinking of the polymer. cr-PEO of crosslinking degrees adequate to confer the required mechanical stability on the swollen matrix can be loaded with no more than 8–10% drug. A polymer with low crosslinking degree was loaded with up to 39% drug, but showed poor mechanical properties in its fully swollen state. The thermal behavior of the PGT-cr-PEO systems, as assessed by DSC, indicates drug-polymer interactions typical of monotectic dispersions. PGT release from cylindrical cr-PEO matrices is not influenced by the matrix swelling kinetics and is consistent with a model assuming that drug diffusion in the polymer phase of the fully swollen hydrogel is the rate-controlling factor. A cr-PEO of comparatively low degree of crosslinking was shown to match uncrosslinked polyethylene glycols with respect to the ability to enhance the dissolution rate of high PGT loads.
Synthesis and characterization of poly (2-acetoxymethyl-3,4-dihydro-2H-pyran)
1996, Polymer Bulletin
Synthesis and characterization of polydi(3,4-dihydro-2H-pyran-2-methyl) adipate hydrogel
1996, Polymer Bulletin
Intravaginal Prostaglandin E<inf>2</inf> Gel and Cardiovascular Changes in Hypertensive Pregnancies
1991, American Journal of Perinatology
Morphology of poly(ethylene oxide)‐based hydrogels in relation to controlled drug delivery
1988, Makromolekulare Chemie. Macromolecular Symposia

^☆: Paper presented at the Second International Symposium on Recent Advances in Drug Delivery Systems, February 27, 28 and March 1, 1985, Salt Lake City, UT, U.S.A.

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Journal of Controlled Release

Abstract

References (24)

Modelling of drug diffusion through swellable polymeric systems

J. Membrane Sci.

Hydrogels for controlled drug delivery

Biomaterials

In vitro release characteristics and long term stability of poly(ethylene oxide) hydrogel vaginal pessaries containing prostaglandin E₂

J. Controlled Release

Vaginal pessaries from crystalline/rubbery hydrogels for the delivery of prostaglandin E₂

J. Controlled Release

Melting point depression in poly(ethylene oxide)-poly(methyl methacrylate) blends

Eur. Polym. J.

The glass transition temperature of poly(N-vinylpyrrolidone) and the effect of water

Polymer

Gas Chromatographic evaluation of thermodynamic interaction parameters for the water-poly(ethylene oxide) system

Polymer

Diffusional release of a solute from a polymer matrix — Approximate analytical solutions

J. Membrane Sci.

Swelling controlled constant rate delivery systems

Induction of labour with a sustained release prostaglandin E₂ vaginal pessary

Br. Med. J.

Polymers of esters of oxygen heterocyclic carbinds

Cited by (5)

A study of controlled-release systems for progesterone based on crosslinked poly(ethylene oxides)

Synthesis and characterization of poly (2-acetoxymethyl-3,4-dihydro-2H-pyran)

Synthesis and characterization of polydi(3,4-dihydro-2H-pyran-2-methyl) adipate hydrogel

Intravaginal Prostaglandin E<inf>2</inf> Gel and Cardiovascular Changes in Hypertensive Pregnancies

Morphology of poly(ethylene oxide)‐based hydrogels in relation to controlled drug delivery

The release of prostaglandin E2 from a novel crystalline-rubbery poly (ethylene oxide) network crosslinked by 3,4-dihydro-2H-pyranyl-2-methyl-(3,4-dihydro-2H-pyran-2-carboxylate)☆

Abstract

J. Membrane Sci.

Biomaterials

J. Controlled Release

J. Controlled Release

Eur. Polym. J.

Polymer

Polymer

Diffusional release of a solute from a polymer matrix — Approximate analytical solutions

J. Membrane Sci.

Swelling controlled constant rate delivery systems

Induction of labour with a sustained release prostaglandin E2 vaginal pessary

Br. Med. J.

Polymers of esters of oxygen heterocyclic carbinds

The release of prostaglandin E₂ from a novel crystalline-rubbery poly (ethylene oxide) network crosslinked by 3,4-dihydro-2H-pyranyl-2-methyl-(3,4-dihydro-2H-pyran-2-carboxylate)☆

Induction of labour with a sustained release prostaglandin E₂ vaginal pessary