Solute and penetrant diffusion in swellable polymers. III. Drug release from glassy poly(HEMA-co-NVP) copolymers

doi:10.1016/0168-3659(84)90001-4

Journal of Controlled Release

Volume 1, Issue 2, December 1984, Pages 89-98

https://doi.org/10.1016/0168-3659(84)90001-4 Get rights and content

Abstract

The dynamic swelling behavior of poly(HEMA-co-NVP) copolymers at 37°C was investigated. The copolymers had widely varying contents of both components. It was observed that the swelling mechanism was non-Fickian, associated with major changes of the thickness and other dimensions of the samples. Theophylline release from initially dry hydrogels gave a quasi-zero order release depending on the copolymer composition and the thickness of the samples.

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^∗: Present address: The B.F. Goodrich Co., Research and Development Center, Brecksville, OH 44141, U.S.A.

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Solute and penetrant diffusion in swellable polymers. III. Drug release from glassy poly(HEMA-co-NVP) copolymers

Abstract

Biomaterials

J. Membrane Sci.

Int. J. Pharmac.

J. Membrane Sci.

Int. J. Pharm.

J. Membrane Sci.

Chemical and physical structure of polymers as carriers for controlled release of bioactive agents

A review, J. Macromol. Sci., Rev. Macromol. Chem. Phys.

Polymeric delivery systems for controlled drug release

Chem. Eng. Commun.

Diffusional release of a solute from a polymeric matrix: Approximate analytical solutions

J. Membrane Sci.

Zero-order drug release from glassy hydrogel beads