ReviewNeopterin as a marker for activated cell-mediated immunity: Application in HIV infection☆
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Ecological, parasitological and individual determinants of plasma neopterin levels in a natural mandrill population
2020, International Journal for Parasitology: Parasites and WildlifeNeopterin levels and Kyn/Trp ratios were significantly increased in dengue virus patients and subsequently decreased after recovery
2020, International Journal of Infectious DiseasesCitation Excerpt :Neopterin concentrations in body fluids are useful in monitoring cellular immune activation (Th1-type) during infections, autoimmune diseases, and malignancies. Increased neopterin concentrations are observed prior to detectable viral antigen-specific IgM antibodies in HIV type 1 (HIV-1), cytomegalovirus (CMV), and rubella infections (Fuchs et al., 1988; Fuchs et al., 1990; Fuchs et al., 1992; Ibarra et al., 2011; Jungraithmayr et al., 2001; Reibnegger et al., 1991). The association of neopterin levels with the DENV severity (in particular with DHF/DSS) has also been reported previously (Chan et al., 2006; Widner et al., 1999).
Estimation of serum neopterin level as an early marker for detecting severe dengue infection
2019, International Journal of Pediatrics and Adolescent MedicineCitation Excerpt :Technological advances may further enhance the usefulness of neopterin measurement in acute infection [12,13]. CPY Chan et al. showed in their study the elevation of serum neopterin concentrations from day 1 of fever onset with a mean neopterin value of 44.2 (2.3)nmol/l to a peak value of 54.3 (3.0) nmol/l on day 4 of fever, and neopterin remained at a higher level, with a mean neopterin value of 30 nmol/l [7]. Similarly, in our study, we observed that the serum neopterin concentration of the second sample with a mean value of 55.0 (10.55) nmol/l was elevated when compared with that of the first sample with a mean value of 49.77 (9.16) nmol/l. K. Babb et al. showed in their study that serum neopterin levels were significantly higher (P = .009) with a median value of 29 nmol/l in patients diagnosed with severe dengue when compared with that of nonsevere dengue with a median value of 13.5 nmol/l [8].
Reversible S-glutathionylation of human 6-pyruvoyl tetrahydropterin synthase protects its enzymatic activity
2019, Journal of Biological ChemistryCitation Excerpt :Furthermore, 7,8-dihydroneopterin, which is derived from NH2TP by the removal of a triphosphate, may act as a scavenger of reactive oxygen species (ROS) (10). The plasma neopterin concentration is often used as a marker for cell-mediated immune activation because activated monocytes/macrophages secrete neopterin (11, 12). When cellular-immunity is activated, GCH in macrophages is induced up to 50-fold, which may exceed endogenous PTS activity, making PTS a rate-limiting step in the BH4 synthesis pathway (13).
Modulation of cell-mediated immunity during pregnancy in wild bonobos
2024, Biology LettersTo Determine The Association Of Serum Neopterin Levels In Sepsis
2023, Research Square
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This work was financially supported by the Austrian research funds ‘Zur Förderung der wissenschaftlichen Forschung’, P 6036M.