Research articleThe anti-HIV activity of the phytochemical α-terthienyl
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α-Terthienyl induces prostate cancer cell death through inhibiting androgen receptor expression
2022, Biomedicine and PharmacotherapyCitation Excerpt :When α-terthienyl worked as herbicidal substance, transketolase was identified as one of its targets. In the field of medicine, α-terthienyl possessed activity against the human immunodeficiency virus when excited by long wavelength light (UVA, 320–400 nm) [21]. However, its anti-prostate cancer effect is unknown.
Plant-microbial interaction: The mechanism and the application of microbial elicitor induced secondary metabolites biosynthesis in medicinal plants
2021, Plant Physiology and BiochemistryCitation Excerpt :Thiarubrine A (another elicitor) from the fungi Protomycesgraidus stimulated the production of secondary metabolites from the cell culture of Ambrosia artemisiifolia (Bhagwath and Hjortsø, 2000). These secondary metabolites exhibited stimulates important biological proprieties such as antibiotic and antiviral activities (Towers et al., 1985; Hudson et al, 1986a, 1993). A study by Schnitzler et al. (1992) showed that the inoculation of carrot (Daucus carota) by cells with mycelial homogenate from Pythium aphanidermatum increased the production of p-hydroxybenzoic acid which exhibited antimicrobial (Orjala et al., 1993; Heleno et al., 2013), allelochemical (Huang et al., 2020), immunotherapeutic (Guo et al., 2020), antifeedant (Chandramu et al., 2003), and molluscicidal effects (Orjala et al., 1993).
Thiophene-derivatized pyridine-biscarboxamide as a sensitizer for Ln<sup>III</sup> luminescence and <sup>1</sup>O<inf>2</inf> generation
2020, Journal of LuminescenceCitation Excerpt :To better control our ability to generate 1O2 efficiently, without sacrificing the benefit of LnIII luminescence, it is advantageous to expand our knowledge of other 1O2 generating functional groups. Oligohiophene-based compounds, such as 2,2’:5’,2’’-terthiophene, have been studied for their antibiotic [32], insecticidal [33–36], antifungal [37,38], and antiviral [39–41] properties, which occur as a result of the compounds’ ability to generate 1O2. Thiophene and methylthiophene can generate 1O2 as well, as verified by ab initio calculations [42].
α-Terthienylmethanol, isolated from Eclipta prostrata, induces apoptosis by generating reactive oxygen species via NADPH oxidase in human endometrial cancer cells
2015, Journal of EthnopharmacologyCitation Excerpt :In addition, terthiophenes were reported to have significant anti-viral and cytotoxic activities against murine cytomegalovirus, sindbis virus, and murine mastocytoma cells (Marles et al., 1992). Anti-HIV (Hudson et al., 1993) and inhibitory activities against protein kinase C (Kim et al., 1998) were also suggested. However, the anti-cancer activity and molecular mechanism of the action of terthiophenes are poorly understood in human cancer cells.
Photochemical and Photophysical Behavior of Thiophene
2011, Advances in Heterocyclic ChemistryCitation Excerpt :Antifeedant activity against larvae of Euxoa messoria was observed: larvae, after a diet containing 100 ppm of a polythiophene derivative in the presence of light decreased the growth rate until death within four weeks (84E577; 84MI104). Polythiophene showed also antiviral and anti-HIV activity (81MI67; 89MI1329; 92PP(56)479; 93MI33; 93PP(58)246; 93MI447; 94MI329; 94PP(60)591). Unfortunately, some phototoxic activity has been found in fishes and some other superior animals (84MI1115; 86MI49; 86MI781; 87MI176).
Cytotoxic properties of thiophenes from Echinops grijissi Hance
2008, Phytomedicine