Review
Messenger plasticity in primary sensory neurons following axotomy and its functional implications

https://doi.org/10.1016/0166-2236(94)90031-0Get rights and content

Abstract

Following peripheral axotomy, long-lasting changes in the expression of neuropeptides and their receptors in primary sensory neurons are observed. These changes involve the downregulation of the excitatory peptides substance P and calcitonin gene-related peptide and the upregulation of the inhibitory peptides neuropeptide tyrosine and galanin, resulting in a reduction of transmission in the dorsal horn. The changes observed are thought to represent adaptive responses to limit the consequences of peripheral nerve damage to the organism as a whole and to promote survival and recovery of the individual neuron.

References (97)

  • R. Dubner et al.

    Trends Neurosci.

    (1992)
  • A.R. Lieberman

    Int. Rev. Neurobiol.

    (1971)
  • G. Grant et al.

    Brain Res.

    (1975)
  • H. Aldskogius et al.

    Brain Res. Rev.

    (1985)
  • T. Takahashi et al.

    Brain Res.

    (1975)
  • V. Miletic et al.

    Brain Res.

    (1988)
  • P.D. Ryu et al.

    Brain Res.

    (1988)
  • Z. Wiesenfeld-Hallin

    Neurosci. Lett.

    (1986)
  • P. Le Greves et al.

    Regul. Pept.

    (1989)
  • J. Mao et al.

    Brain Res.

    (1992)
  • Z. Wiesenfeld-Hallin

    Neurosci. Lett.

    (1984)
  • C.J. Woolf et al.

    Neurosci. Lett.

    (1986)
  • T.E. Salt et al.

    Neuroscience

    (1983)
  • T. Hökfelt

    Neuron

    (1991)
  • T. Jessell et al.

    Brain Res.

    (1979)
  • K. Noguchi et al.

    Mol. Brain Res.

    (1990)
  • G.P. McGregor

    Neuroscience

    (1984)
  • S.A.S. Shehab et al.

    Brain Res.

    (1986)
  • K. Tatemoto et al.

    FEBS Lett.

    (1983)
  • T. Hökfelt et al.

    Neurosci. Lett.

    (1987)
  • M.J. Villar

    Neuroscience

    (1989)
  • H. Kashiba et al.

    Brain Res.

    (1992)
  • S.E. Doughty et al.

    Regul. Pept.

    (1991)
  • S. Wakisaka et al.

    Neurosci. Lett.

    (1991)
  • S. Wakisaka et al.

    Brain Res.

    (1992)
  • P.D. Wall et al.

    Neuroscience

    (1981)
  • Z. Wiesenfeld-Hallin et al.

    Neurosci. Lett.

    (1990)
  • K. Yashpal et al.

    J. Chem. Neuroanat.

    (1991)
  • M. Yanagisawa et al.

    Neurosci. Lett.

    (1986)
  • R.A. Cridland et al.

    Neuropeptides

    (1988)
  • Z. Wiesenfeld-Hallin et al.

    Brain Res.

    (1989)
  • Y. Kuraishi

    Pain

    (1991)
  • Z. Wiesenfeld-Hallin et al.

    Neurosci. Lett.

    (1990)
  • G. Ju

    Neurosci. Lett.

    (1986)
  • K. Fuji

    Neuroscience

    (1985)
  • X-J. Xu

    Neurosci. Lett.

    (1993)
  • S. Kar et al.

    Brain Res.

    (1992)
  • C. Eva et al.

    FEBS Lett.

    (1990)
  • A.W. Duggan et al.

    Neuroscience

    (1991)
  • X. Zhang

    Neuroscience

    (1993)
  • D.S. Bredt et al.

    Neuron

    (1992)
  • J.E. Haley et al.

    Neuroscience

    (1992)
  • R. Morris et al.

    Neurosci. Lett.

    (1992)
  • M. Fitzgerald et al.

    Brain Res.

    (1985)
  • S.B. McMahon et al.

    Neurosci. Lett.

    (1987)
  • U. Arvidsson

    NeuroReport

    (1993)
  • E. Weihe et al.
  • G.W. Kreutzberg
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