Review
Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers

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Abstract

GTP-binding (G) proteins transduce receptor-mediated signals for a variety of effector systems (adenylate cyclase, cyclic nucleotide phosphodiesterases, ion channels and phospholipase C). This review describes another effector system that is linked to a G protein — phospholipase A2. Upon activation of phospholipase A2 by a receptor-coupled G protein, arachidonic acid and its numerous biologically active metabolites are generated. Arachidonic acid as well as some of the arachidonate metabolites can act as first and second messengers. In some cases, arachidonate and its metabolites interact with other transducing systems to modulate or amplify their signals.

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