Trends in Pharmacological Sciences
ReviewA mechanism for P-glycoprotein action in multidrug resistance: are we there yet?
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Cited by (59)
A Critical View on In Vitro Analysis of P-glycoprotein (P-gp) Transport Kinetics
2017, Journal of Pharmaceutical SciencesCitation Excerpt :Energetically, the release of a dehydrated lipophilic substrate to the outer leaflet of the plasma membrane would be more favorable than transport directly into the aqueous cell exterior followed by hydration. The transporter ABCB4, a member of the ABC transporter family and structurally similar to P-gp, is believed to export phosphatidylcholine into bile via a flippase mechanism, lending support to the notion that P-gp also may act like a flippase.27,28 The structure, function, and transport mechanisms of P-gp has previously been reviewed extensively.19,29-32
P-glycoprotein and its inhibition in tumors by phytochemicals derived from Chinese herbs
2012, Journal of EthnopharmacologyCitation Excerpt :Roepe (1995) proposed that P-glycoprotein affects the intracellular pH values and that drugs diffuse down the pH gradient out of the cells. However, this model was quite controversial (Ruetz and Gros, 1994; Germann, 1996). Raviv et al. (1990) suggested a “vacuum cleaner” model in which intramembranous molecules non-native to the membrane are recognized and taken up by P-glycoprotein and moved out of the cell.
Effect of oral contraceptives on the transport of chlorpromazine across the CACO-2 intestinal epithelial cell line
2003, European Journal of Pharmaceutics and BiopharmaceuticsAntiproliferative prostaglandins and the MRP/GS-X pump role in cancer immunosuppression and insight into new strategies in cancer gene therapy
2001, Biochemical PharmacologyCitation Excerpt :Several ABC membrane transporters have been described in this context, and these export proteins may account for the elimination of antiproliferative substances. The ABC transporter family comprises a variety of carriers involved in the expression of the multidrug resistance (MDR) phenotype, including the small subfamily of 170-kDa plasma membrane glycoproteins (P-glycoproteins or P-170) encoded by the MDR genes [30]. Apart from these gene products, another member of the ABC transporter family has been characterized recently as a non-P-glycoprotein carrier associated with the MDR phenomenon [31].
Expression of P-glycoprotein in southeastern oysters, Crassostrea virginica
2001, Marine Environmental Research