Elsevier

Immunology Letters

Volume 12, Issue 4, April 1986, Pages 237-242
Immunology Letters

Phenotype correction of Ir-genic control of immune response to (T,G)-A-L conjugated to synthetic polyelectrolytes

https://doi.org/10.1016/0165-2478(86)90010-6Get rights and content

Abstract

Experiments in CBA (H-2k) and C57BL/6 (H-2b) strains of mice have shown (T,G)-A-L covalently bound to synthetic polyelectrolytes possessing immunoadjuvant effect to induce a pronounced antibody and cell-mediated immune response irrespective of murine genotype. When conjugated to the polyelectrolytes (T,G)-A-L was also found to acquire the properties of a highly immunogenic thymus-independent antigen. Thus, (T,G)-A-L-synthetic polyelectrolyte conjugates manifested the effects of highly immunogenic thymus-independent antigens inducing a potent Ir-1-independent immune response. It provided for the transformation of genetically low responder individuals into high responder ones.

References (25)

  • A. Chapiro et al.

    Eur. Polymer J.

    (1974)
  • R.V. Petrov et al.

    DAN SSSR

    (1977)
  • V.A. Kabanov et al.

    DAN SSSR

    (1978)
  • R.V. Petrov et al.

    Uspekhi Sov. Biol.

    (1979)
  • V.A. Kabanov et al.

    Sov. Sci. Rev. D. Physicochem. Biol.

    (1984)
  • R.V. Petrov et al.

    DAN SSSR

    (1979)
  • R.V. Petrov et al.

    DAN SSSR

    (1984)
  • R.V. Petrov et al.

    DAN SSSR

    (1984)
  • I.V. Vinogradov et al.

    DAN SSSR

    (1982)
  • R.V. Petrov et al.
  • R.V. Petrov et al.

    Immunologiya

    (1984)
  • H.O. McDevitt et al.

    J. Exp. Med.

    (1967)
  • Cited by (0)

    View full text