Stress-related impairments in cellular immunity
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Inflammation: A Proposed Intermediary Between Maternal Stress and Offspring Neuropsychiatric Risk
2019, Biological PsychiatryCitation Excerpt :Decades of research have established that psychosocial stress dysregulates aspects of immune function in healthy nonpregnant adults (21–28).
Impact of stress on aged immune system compartments: Overview from fundamental to clinical data
2018, Experimental GerontologyChildhood adversity and cell-mediated immunity in young adulthood: Does type and timing matter?
2013, Brain, Behavior, and ImmunityReactivation of latent viruses is associated with increased plasma cytokines in astronauts
2013, CytokineCitation Excerpt :Reactivation of herpes simplex virus (HSV) type 1, EBV, VZV, and CMV is a frequent occurrence during and after short-duration spaceflight [6,7]. Although the precise molecular mechanism for reactivation of latent herpes viruses is unknown, numerous studies have demonstrated that reactivation commonly follows stress-related reductions in immunity [15–18]. The viral and immunological findings associated with spaceflight best fits the model of reduced activity of cytotoxic T-cells due to stress induced activation of the HPA-axis and the SNS.
Stress hormones and immune function
2008, Cellular ImmunologyCitation Excerpt :In this study RU486 alone had no effect on CTL activation but RU486 and nadolol together fully reverse restraint stress suppression of HSV-1 CTL activation suggesting that both glucocorticoids and catecholamines are involved in stress-induced suppression of CTL activation [10]. We have also shown a poor T lymphocyte proliferation response to PHA or Con A in psychiatric patients who had high scores on the UCLA loneliness scale [16], in patients who had recently undergone surgery for breast cancer [64,75], in caregivers of dementia patients [76], in medical students undergoing exam stress [68], in women with poor marital quality [77], in subjects who exhibited more negative or hostile behaviors following a discussion on marital problems [63], and following a mental arithmetic stress test [38]. Interestingly intervention therapy in small group sessions reduced stress, improved mood, changed health behaviors and helped compliance in the maintenance of cancer treatment.
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Ronald Glaser, Ph.D., is Professor and Chairman of the Department of Medical Microbiology and Immunology. Dr. Glaser is also associated with the Comprehensive Cancer Center. Janice K. Kiecolt-Glaser, Ph.D., is an Associate Professor in the Department of Psychiatry. Julie C. Stout, B.A., is a research assistant, and Kathleen L. Tarr, B.S., is a graduate student in the Department of Medical Microbiology and Immunology. Carl E. Speicher, M.D., is Professor and Director of Clinical Laboratories in the Department of Pathology. Jane E. Holliday is a research associate in the Department of Medical Microbiology and Immunology. All are in The Ohio State University College of Medicine, 333 West 10th Ave., Columbus, OH 43210, USA.