PaperDegradation of poly(d,l-lactic acid) nanoparticles coated with albumin in model digestive fluids (USP XXII)
References (34)
Peroral administration of nanoparticles
Adv Drug Del Rew
(1991)- et al.
Disposition kinetics and oral bioavailability of vincamine-loaded polyalkyl cyanoacrylate nanoparticles
J Pharm Sci
(1986) Persorption of particles: physiology and pharmacology
Pharmacol Chemother
(1977)- et al.
Nanospheres and microspheres uptake via Peyer's patches: observation on the rate of uptake in the rat after single oral dose
Int J Pharm
(1992) - et al.
Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the Payer's patches
J Contr Rel
(1990) - et al.
The enzymatic surface erosion of aliphatic polyesters
J Contr Rel
(1984) - et al.
Polymers for biodegradable medical devices. 1. The potential of polyesters as controlled macromolecular release systems
J Contr Rel
(1986) - et al.
Adsorption of proteins onto polymeric surfaces of different hydrophilicities
J Colloid Interface Sci
(1988) - et al.
Pharmacokinetic evaluation of indomethacin nanocapsules
Drug Design Delivery
(1989) - et al.
New approach for oral administration of insulin with poly-alkylcylanoacrylate nanocapsules as drug carriers
Diabetes
(1988)
Transmucosal passage of polyalkylcyanoacrylate nanocapsules as a new drug carrier in the small intestine
Biol Cell
Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency
J Pharm Pharmacol
Intestinal barrier to large particulates in mice
J Toxicol Environ Health
Biodegradable polymers for sustained drug delivery
Contemp Top Polym Sci
An in vitro evaluation on the stability of mechanical properties of surgical suture materials in various pH conditions
Ann Surg
Mechanism of hydrolytic degradation of poly(l-lactide) microcapsules: effect of pH, ionic strength and buffer concentration
J Microenc
Melt spining of poly-llactide and hydrolysis of the fiber in vitro
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2018, European Journal of Pharmaceutics and BiopharmaceuticsCitation Excerpt :As expected, due to the important exposure to the enzymes of the oily core of the NE prepared without non-ionic surfactants, this was the formulation that presented the highest degradation by pancreatic enzymes (70% in 20 min), being its area under the curve significantly higher than those corresponding to CS NCs (p ≤ 0.0001) and PARG NCs (p ≤ 0.001). This was mainly attributed to the interaction of the pancreatic lipase with the oily droplets [19,60,68], being this degradation slightly reduced by the CS and PARG coatings. We have speculated that this limited protective effect of the polymeric shell could be attributed to the presence of amylases, enzymes with the capacity of degrading CS through the α(1,4) glycosidic bond cleavage [69–71], and peptidases, enzymes capable of degrading PARG backbone through the peptide bond [68,72].
Fab-conjugated PLGA nanoparticles effectively target cancer cells expressing human CD44v6
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