5-FU loaded pHEMA drainage implants for glaucoma-filtering surgery: device design and in vitro release kinetics*
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Sustained prevention of biofilm formation on a novel silicone matrix suitable for medical devices
2015, European Journal of Pharmaceutics and BiopharmaceuticsCitation Excerpt :Since this accounts for a large fraction of the total released amount of drug, the result is a poor fit. The diffusion coefficients are all in the range of 109 cm2/s, which is at least a factor of 10 lower than what has been previously reported in literature for diffusion of small molecules in HEMA-based hydrogels [25–27]. This reduction in Dapp can be expected as the matrix is considered to have a highly restricted and tortuous diffusion path when compared to PHEMA gels not incorporated into a matrix.
Mechanisms of diphylline release from dual-solute loaded poly(vinyl alcohol) matrices
2014, Materials Science and Engineering CCitation Excerpt :Thus, even for the lowest diphylline load studied (2% w/w), the total solute initially present in the matrix is 13% w/w, and the measured equilibrium water uptake of the depleted matrix is distinctly higher than that of pure PVA and of PVA loaded solely with 2% diphylline (Table 1). Gökce et al. [38] report acceleration of release rate with increasing drug load in PHEMA matrices loaded with 5-fluoracil, although the Tg of the loaded matrix was found higher than that of the drug-free polymer. The said acceleration was correlated with the corresponding equilibrium water uptake of the matrices, which was also found to increase with increasing drug load.
Molecular dynamics simulation study of P (VP-co-HEMA) hydrogels: Effect of water content on equilibrium structures and mechanical properties
2009, BiomaterialsCitation Excerpt :Since the landmark development of poly (2-hydroxyethyl methacrylate) (PHEMA) in the early 1960s by Wichterle and Lim [4], various types of hydrogels have been studied intensively over the last 50 years as promising biomaterials for medical and pharmaceutical applications [5–12], including drug delivery and tissue engineering. PHEMA is one of the most important synthetic hydrogels that has been extensively developed in biomedical applications, and has been widely exploited for contact lenses [13] and drug delivery [14–17]. The utility of PHEMA is derived from its good mechanical properties, optical transparency and stability in water.
Diclofenac sodium releasing pH-sensitive monolithic devices
2002, International Journal of Pharmaceutics
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A part of this study was presented at ARVO meeting, Saratosa, May 1994.