Surface-immobilized polyethylene oxide for bacterial repellence

doi:10.1016/0142-9612(92)90160-P

Biomaterials

Volume 13, Issue 7, 1992, Pages 417-420

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Abstract

Polyethlene terephthalate films were surface-modified with polyethylene oxide (18 500 g/mol) using a solution technique described previously. These films were investigated for their resistance to bacterial adhesion. Three bacterial strains most commonly associated with implant infections, Staphylococcus epidermidis, Staphylococcus aureus and Pseudomonas aeruginosa, were cultured in tryptic soya broth, human plasma and human serum on the polymeric substrates. Significant reductions (between 70 and 95%) in adherent bacteria were observed on the polyethylene oxide-modified substrates compared to the untreated control polyethylene terephthalate. Surface modification with polyethylene oxide may reduce the risk of implant-associated infections. Plasma fibrinogen was observed to play an important role in the adhesion of all three of these species on both the polyethylene oxide-modified and control polyethylene terephthalate materials.

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^∗: Present address: Vico Rx Inc, 12703 Dorothy Street, Los Angeles, CA 90049, USA.

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Surface-immobilized polyethylene oxide for bacterial repellence

Abstract

Biomaterials

Biomaterials

Biomaterials

Biomaterials-centred infection: microbial adhesion versus tissue integration

Science

Infections of vascular grafts: incidence, anatomic location, etiologic agents, morbidity and mortality

Postmortem microbiological findings of two total artificial heart recipients

J. Am. Med. Assoc.

Adherence of coagulase-negative staphylococci to plastic tissue culture plates: a quantitative model for the adherence of staphylococci to medical devices

J. Clin. Microbiol.

The microbiology of explanted vascular prosthesis

Surgery