Preliminary studies on the phenomenological behaviour of osteoblasts cultured on hydroxyapatite ceramics

doi:10.1016/0142-9612(90)90052-R

Biomaterials

Volume 11, Issue 1, January 1990, Pages 50-56

https://doi.org/10.1016/0142-9612(90)90052-R Get rights and content

Abstract

SEM was used to investigate the phenomenological behaviour of osteoblasts towards sintered hydroxyapatite. The osteoblasts were seeded on to porous and dense hydroxyapatite and cultured for 4 to 28 d. They attached and adhered on to the hydroxyapatite surfaces, proliferated and secreted extracellular matrix. No signs of toxicity embarassment were apparent. It is argued that cell phenomenology seems to be a prerequisite to morphogenesis, and on this premise it is speculated that surface-reactive bone replacement materials owe their compatibility to the ability of their surfaces to interact favourably with the peptides involved in osteomorphogenesis and bone repair.

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PaperPreliminary studies on the phenomenological behaviour of osteoblasts cultured on hydroxyapatite ceramics

Abstract

Adv. Biomed. Eng.

Cell Res.

J. Theor. Biol.

Biophys. J.

Exp. Cell Res.

J. Biol. Chem.

Cell

Cell

Cell

Exp. Cell Res.

J. Biol. Chem.

J. Biol. Chem.

Biochem. Biophys. Res. Commun.

Biomaterials: An Interfacial Approach

Bonding mechanisms at the interface of ceramic prosthetic materials

Direct chemical bond of bioactive glass-ceramic materials to bone and muscle

Bone formation at a ceramic implant interface

Calcif. Tissue Res.

A histological comparison of the tissue interface of bioglass and silica glass

J. Biomed. Mater. Res.

Tissue cellular, and subcellular events at a bone-ceramic interface

J. Bioeng.

Epithelial attachment of bone tissue formation to the surface of hydroxyapatite ceramics dental implants

Die biologische Reaktion auf den Knochenersatz-werkstoff Hydroxyapatit-Keramik

Anchorage and growth regulation in normal and virus transformed cells

Int. J. Cancer

Role of cell shape in growth control

Nature

The role of fibronectin and substrate size in attachment of rat bone marrow cells to an osteoinductive matrix

A new in vitro model of intramembranous osteogenesis from adult bone marrow cells

Synthesis and localisation of fibronectin during collagenous matrix mesenchymal cell interaction and differentiation of cartilage and bone in vivo

Appearance of fibronectin during the differentiation of cartilage, bone and bone marrow

J. Cell Biol.

Bone cell histogenesis: The skeletoblast as a stem-cell for preosteoblasts and for secondary type prechondroblasts

Retrovirus-induced osteopetrosis in mice: Effects of viral infection on osteogenic differentiation in skeletoblast cell cultures

Am. J. Pathol.

The mechanisms of adhesion of cells to glass: a study by interference reflection microscopy

J. Cell Biol.

Haptotaxis and the mechanism of cell motility

Nature (Lond)

Studies on cell adhesion. II. Adhesion of cells to surfaces of diverse chemical composition and inhibition of adhesion by sulfhydryl binding reagents

Arch. Biochem. Biophys.

Paper
Preliminary studies on the phenomenological behaviour of osteoblasts cultured on hydroxyapatite ceramics