Cell
MinireviewARF signaling: A potential role for phospholipase D in membrane traffic
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Lipids: Phospholipase D
2021, Encyclopedia of Biological Chemistry: Third EditionLipidated proteins: Spotlight on protein-membrane binding interfaces
2017, Progress in Biophysics and Molecular BiologyCitation Excerpt :Remarkably, this lipid anchor provides a basis for spatio-temporal segregation of these proteins and thereby orchestrating efficient signal transduction. Lipidated proteins are key players responsible for broad spectrum of biological functions, including, regulation of cellular trafficking (Kahn et al., 1993; Aicart-Ramos et al., 2011; Resh, 2006), signaling (Casey, 1995) and various transport activities (Pechlivanis and Kuhlmann, 2006; Stenmark, 2009). The family of Ras proteins is a paradigm example of this spatial organization of lipidated proteins.
Phospholipase D in the Golgi apparatus
2009, Biochimica et Biophysica Acta - Molecular and Cell Biology of LipidsSorting through the Cell Biology of Alzheimer's Disease: Intracellular Pathways to Pathogenesis
2006, NeuronCitation Excerpt :Pathogenic PS1 mutations retard egress of APP from the TGN by a mechanism that appears to involve phospholipase D (Cai et al., 2006a, 2006b), a known TGN budding modulator (Kahn et al., 1993). It is clear that the mutations that have been tested so far increase the residence time at the TGN while also increasing the Aβ42/40 ratio (Kahn et al., 1993). Recent data suggest that TGN retention per se can increase generation of Aβ42/40 in cerebral neurons in vivo, indicating that abnormal post-TGN trafficking of APP might be sufficient to initiate Aβ accumulation (S.G. et al., unpublished data).
Conformational changes in human Arf1 on nucleotide exchange and deletion of membrane-binding elements
2004, Journal of Biological ChemistryExpression and regulation of phospholipase D isoforms in sphingosine and phorbol ester-stimulated glioma C6 cells
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