Cell
Volume 70, Issue 1, 10 July 1992, Pages 31-46
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Cell death and control of cell survival in the oligodendrocyte lineage

https://doi.org/10.1016/0092-8674(92)90531-GGet rights and content

Abstract

Dead cells are observed in many developing animal tissues, but the causes of these normal cell deaths are mostly unknown. We show that about 50% of oligodendrocytes normally die in the developing rat optic nerve, apparently as a result of a competition for limiting amounts of survival signals. Both platelet-derived growth factor and insulin-like growth factors are survival factors for newly formed oligodendrocytes and their precursors in culture. Increasing platelet-derived growth factor in the developing optic nerve decreases normal oligodendrocyte death by up to 90% and doubles the number of oligodendrocytes in 4 days. These results suggest that a requirement for survival signals is more general than previously thought and that some normal cell deaths in nonneural tissues may also reflect competition for survival factors.

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    Present Address: Neurosciences Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU.

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