Cell

Cell

Volume 56, Issue 1, 13 January 1989, Pages 27-35
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The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

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Abstract

Staphylococcal enterotoxin B is known to be a powerful T cell stimulant in mouse and man. In this paper we show that, for mice, this is because the protein in association with major histocompatibility complex class II molecules stimulates virtually all T cells bearing Vβ3 and Vβ8.1, 8.2, and 8.3, and few others. Neonatal mice given the enterotoxin eliminate all mature, and some immature, T cells bearing these Vβs, demonstrating that tolerance to exogenously administered antigen can be caused by clonal deletion of reactive T cells. The enterotoxin shares these “superantigenic” properties with known self-antigens in mice, Mis-1a and Mis-2a, and a B cell-derived product, a shared property that is unlikely to be coincidental or inconsequential.

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