Cell
ArticleSteroid hormone receptors compete for factors that mediate their enhancer function
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2022, Biosensors and BioelectronicsCitation Excerpt :We wondered if we could fine-tune the system further, boosting the growth and fluorescent signal of pCu4-CUP2 cells while retaining their extreme Cu2+ sensitivity. As overexpressed transactivators can slow growth through overly strong activation domains (Gill and Ptashne, 1988; Meyer et al., 1989), we tried to pinpoint the Cup2 activation domain. Alphafold's prediction of Cup2 structure (Fig. 4A, Uniprot Accession P15315) showed that the transactivator's DNA-binding and regulatory regions, residing in the N-terminal half of the protein, were well-structured.
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2021, Molecular and Cellular EndocrinologyRepression of transcription by the glucocorticoid receptor: A parsimonious model for the genomics
2021, Journal of Biological ChemistryCitation Excerpt :Other studies suggested that inductive transcriptional complexes nucleated by GR included cofactors that were recruited from other active enhancers and promoters (63). This competition consequently resulted in reduced expression of a subset of genes that are regulated by these cofactors (64, 65). Determinants of the GRE itself were also implicated (66), and GR interactions with specific DNA sequences known as negative GREs (67), which differ from canonical high-affinity GR binding sequences, were reported to result in repression rather than induction (67, 68).