Cell
ArticleCellular ras activity and phospholipid metabolism
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2013, Biochimica et Biophysica Acta - Reviews on CancerCitation Excerpt :Activation of KRAS (G12V) decreases mitochondrial glucose oxidative phosphorylation, but increases glycolysis in cells [49]. Additionally, RAS stimulates phospholipid metabolism via up-regulation of either phospholipase C or phospholipase A2 activity in the inositol phospholipid signaling pathway [50–52]. Thus, RAS-mediated oncogenic metabolic reprogramming, including glycolysis and lipid metabolism, is vital to support cancer cell growth [53].
Lysophosphatidylinositol signalling: New wine from an old bottle
2012, Biochimica et Biophysica Acta - Molecular and Cell Biology of LipidsCitation Excerpt :In this study Moolenaar and his co-workers revealed that LPA derived from phosphatidic acid (PA) was able to act as mitogenic stimulus inducing cell proliferation [6]. The mitogenic activity of PA was previously reported by these authors and others in quiescent normal fibroblasts [7–9], but this study showed that among different PA-derived lipids, only LPA exerts a mitogenic effect for quiescent normal cells [6]. It is also noteworthy that the mitogenic effect of LPA was observed in a wide range of cells, including normal and transformed cells.