Cell
ArticleAppppA and related adenylylated nucleotides are synthesized as a consequence of oxidation stress
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Crosstalk between (p)ppGpp and other nucleotide second messengers
2023, Current Opinion in MicrobiologyRecent insights into noncanonical 5′ capping and decapping of RNA
2022, Journal of Biological ChemistryCitation Excerpt :Dinucleotide polyphosphates (NpnNs) were initially discovered as reaction intermediates of aminoacyl-tRNA synthetase–catalyzed reactions in vitro (20). Subsequent reports of the involvement of these molecules in stimulating DNA replication in quiescent human cells (21) and an approximately 100-fold increase in their concentration within 30 min following exposure to oxidative or heat shock stress emphasized their key physiological role as the signaling molecules that alert cells to the onset of specific metabolic stresses—hence named “alarmones” (22, 23). Although these molecules have been detected both in prokaryotes and eukaryotes, their precise function remained elusive.
Regulation of RNA processing and degradation in bacteria
2020, Biochimica et Biophysica Acta - Gene Regulatory MechanismsCitation Excerpt :This large spectrum of 5′-end modifications of RNAs allows post-transcriptional regulation of gene expression in response to stress. Interestingly, NAD, CoA and Np4N are all involved in sensing and/or defense against oxidative stress, suggesting that RNA degradation is highly regulated in these conditions [86,87]. In eukaryotes, N6-methyladenosine (m6A) is a common modification found in mRNAs, with an impact on mRNA stability.
Stresses that Raise Np<inf>4</inf>A Levels Induce Protective Nucleoside Tetraphosphate Capping of Bacterial RNA
2019, Molecular CellCitation Excerpt :Over the ensuing decades, they have been found in all realms of life, both prokaryotic and eukaryotic (Plateau and Blanquet, 1994; Kisselev et al., 1998), and, despite scant evidence as to their mechanism of action in any organism, have come to be regarded as signaling molecules. For example, in bacteria, where their concentration increases during oxidative stress and heat shock (Lee et al., 1983; Bochner et al., 1984; Coste et al., 1987), dinucleoside tetraphosphates are thought to act as alarmones, i.e., as second messengers for stress (Varshavsky, 1983). In eukaryotes, these molecules have been implicated in immune responses, neuronal signaling, and cardiovascular function (Boulos et al., 2016).
The Plasma Membrane Purinoreceptor P2K1/DORN1 Is Essential in Stomatal Closure Evoked by Extracellular Diadenosine Tetraphosphate (Ap<inf>4</inf>A) in Arabidopsis thaliana
2023, International Journal of Molecular Sciences
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