Photoactive antiviral and cytotoxic activities of synthetic thiophenes and their acetylenic derivatives

doi:10.1016/0045-6535(89)90080-5

Chemosphere

Volume 19, Issues 8–9, 1989, Pages 1329-1343

https://doi.org/10.1016/0045-6535(89)90080-5 Get rights and content

Abstract

A total of 31 thiophenes were tested for phototoxicity against two membrane-containing viruses, and for cytotoxicity, in comparison with the known potent phototoxic thiophene α-terthienyl. Several compounds were more potent against viruses, but were much less cytotoxic than α-terthienyl. The key structural features of the most active compounds were the possession of a conjugated linear configuration of two or three thiophene rings and a substituent with an acetylenic linkage. Some of these derivatives could constitute useful therapeutic agents against infectious diseases or cancer.

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Photoactive antiviral and cytotoxic activities of synthetic thiophenes and their acetylenic derivatives

Abstract

Tetrahedron

Chemosphere

Biochem. Biophys. Acata.

J. Immunol. Meth.

Tetrahedron

Photosensitization of E. coli and S. cerevisiae by phenylheptatriyne from Bidens pilosa

L. Can. J. Microbiol.

Phototoxicity of naturally occurring and synthetic thiophenes and acetylenic analogues to mosquito larvae

Phytochemistry

Naturally occurring acetylenes

Comparison of the phototoxicity of α-terthienyl with that of a selenium and of an oxygen analogue

Photochem. Photobiol.

Nature of the interaction between the photoactive compound phenylheptatriyne and animal virus

Photochem. Photobiol.