Acute inhalation toxicity of 3-methylfuran in the mouse: Pathology, cell kinetics, and respiratory rate effects☆,☆☆
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Selected Pneumotoxic Agents
2018, Comprehensive Toxicology: Third EditionA 90-day subchronic gavage toxicity study in Fischer 344 rats with 3-methylfuran
2018, Food and Chemical ToxicologyCitation Excerpt :Until recently, little attention had been paid to the effects and presence of methylfurans in foods until 2-methylfuran and 3-methylfuran were identified to be potent hepatotoxins (Wiley et al., 1984; Ravindranath et al., 1984; Ravindranath and Boyd, 1991). Little toxicological information was available for 3-methylfuran and in most of the available studies, the route of administration was by inhalation (Haschek et al., 1983;1984; Morse et al., 1984; Gammal et al., 1984) or intraperitoneal injection. With inhalation studies, furan, 2-methylfuran and 3-methylfuran were found to induce pulmonary, nasal and kidney toxicity (Gammal et al., 1984; Haschek et al., 1983;1984; Morse et al., 1984; Ravindranath et al., 1984; Witschi et al., 1985).
Selected Pneumotoxic Agents
2010, Comprehensive Toxicology, Second EditionCell Damage and Cell Renewal in the Lung
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2004, The Lung: Development, Aging and The EnvironmentProliferation during early phases of bronchiolar repair in neonatal rabbits following lung injury by 4-ipomeanol
2003, Toxicology and Applied Pharmacology
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The U.S. Government's right to retain a nonexclusive, royalty-free license in and to any copyright covering this paper, for governmental purposes, is acknowledged.
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This research was sponsored by the Office of Health and Environmental Research, U.S. Department of Energy under Contract W-7405-eng-26 with the Union Carbide Corporation. Dr. Hakkinen was supported as a postdoctoral investigator by Subcontract 3322 from the Biology Division, Oak Ridge National Laboratory, to the University of Tennessee.
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Present address: University of Illinois, Department of Veterinary Pathobiology, Urbana, Ill.
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Present address: National Cancer Institute, Bethesda, Md.
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Present address: The Procter and Gamble Company, Cincinnati, Ohio.