2,3,7,8-Tetrachlorodibenzo-p-dioxin: Failure to demonstrate toxicity in twenty-three cultured cell types☆
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Cited by (73)
In vitro toxicity and in silico docking analysis of two novel selective AH-receptor modulators
2018, Toxicology in VitroCitation Excerpt :C1 and C3 were first assessed for their in vitro toxicity, in some cases in parallel with TCDD, to further compare their effects. Generally, TCDD is not overtly toxic to cultured cells in vitro, despite its drastic effects in vivo (Beatty, et al. 1975, Knutson and Poland 1980, Schecter, et al. 1987). However, the same could not be taken for granted for C1 and C3, particularly because in vivo, we had observed some effects with C2 and C4 that have not been reported with TCDD.
2,3,7,8-Tetrachlorodibenzo-p-dioxin differentially suppresses angiogenic responses in human placental vein and artery endothelial cells
2015, ToxicologyCitation Excerpt :The current observations that TCDD decreased cell proliferation and viability is the first report, as far as we are aware, to directly show the TCDD’s inhibitory effects on proliferation and viability of primary HUVECs and HUAECs. These observations are contrary to the previous studies (Beatty et al., 1975; Knutson and Poland, 1980), in which TCDD at 100 nM or 1 μM failed to affect growth and viability of 27 human and animal primary cultures and transformed cell lines (not including HUVECs and HUAECs), derived from tissues and/or species susceptible to TCDD toxicity in vivo. Nonetheless, our finding is consistent with a previous report, which showed that benzo[a]pyrene (another AhR exogenous ligand) inhibited angiogenic factors-induced neovasculogenesis and angiogenic activity of HUVECs (Li et al., 2010).
Chloracne: From clinic to research
2012, Dermatologica SinicaCitation Excerpt :Exposure of murine fetuses in utero to TCDD led to an accelerated terminal differentiation of fetal skin.29 A survey of 23 cell lines displayed no changes in morphology, viability, or growth patterns following treatment with TCDD.30 Furthermore, TCDD caused the acceleration of differentiation of a spontaneously immortalized human keratinocyte cell line in a three-dimensional skin equivalent model as determined by morphologic characterization and by immunohistochemistry for several differentiation-specific protein markers.
2,3,7,8-Tetrachlorodibenzo-p-dioxin alters the differentiation pattern of human keratinocytes in organotypic culture
2001, Toxicology and Applied PharmacologyThe Ah receptor is not involved in 2,3,7,8-tetrachlorodibenzo-p-dioxin- mediated apoptosis in human leukemic T cell lines
1998, Journal of Biological Chemistry
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Supported in part by National Institute of Environmental Health Science Grant 1-R01-ES-00965 and National Cancer Institute Core Grant CA-07175.
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Recipient of Research Career Development Award K-04 ES-0017.