Diastereoselective alkylation of sultam-derived amino acid aldimines preparation of Cα-methylated amino acids

doi:10.1016/0040-4039(95)00683-4

Tetrahedron Letters

Volume 36, Issue 23, 5 June 1995, Pages 4069-4072

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Abstract

Alkylation of Schiff bases 2 derived from 4-chlorobenzaldehyde and sultam-derived amino acids 1 gave crystalline diastereomers 3 which after deprotection and re-crystallization, if necessary, afforded in good yield enantiomerically pure Cα′-methylated amino acid (ex: αMePhe, αMeLeu, αMeMet).

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Tetrahedron Letters

Diastereoselective alkylation of sultam-derived amino acid aldimines preparation of Cα-methylated amino acids

Abstract

Tetrahedron Lett.

Tetrahedron: Asymmetry

Tetrahedron Lett.

J. Am. Chem. Soc.

Helv. Chim. Acta

J. Org. Chem.