Synthesis of hydroperoxide via photooxygenation for a model aequorin bioluminescence
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Near-infrared chemiluminescence imaging of superoxide anion production in kidneys with iron<sup>3+</sup>-nitrilotriacetate-induced acute renal oxidative stress in rats
2022, Journal of Photochemistry and Photobiology B: BiologyCitation Excerpt :MCLA-800 consists of chemiluminescent imidazopyrazinone and near-infrared fluorescent indocyanine moieties. The imidazopyrazinone structure possesses a common skeleton found in marine bioluminescent substrates such as coelenterazine (Gaussia luciferin, Renilla luciferin), Watasenia luciferin, and Cypridina luciferin [28], which enzymatically or non-enzymatically react with molecular oxygen and emits blue light via peroxide, dioxetanone, and excited amide molecules (Fig. 1b) [29–31]. Coelenterazine and its artificial analogs, including MCLA are used for the selective detection of O2•– [32–39].
Non-invasive and accurate readout of superoxide anion in biological systems by near-infrared light
2021, Analytica Chimica ActaCitation Excerpt :Moreover, coelenterazine and its structural analogues, including MCLA, can emit blue light via a reaction with O2•– [25–28]. The chemical mechanisms underlying these imidazopyrazinone compounds are believed to be the production of hydroperoxide intermediates, according to an insight obtained in a previous study (Fig. 1c) [29]. Because the imidazopyrazinone compounds do not enhance O2•– generation and they produce blue light in an O2•–-selective manner in biological specimens, they exhibit reliability for O2•– analysis [20,30,31].
Luminescence of imidazo[1,2-a]pyrazin-3(7H)-one compounds
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