Elsevier

Tetrahedron Letters

Volume 32, Issue 43, 21 October 1991, Pages 6085-6088
Tetrahedron Letters

A novel approach to the synthesis of enediynes

https://doi.org/10.1016/0040-4039(91)80759-YGet rights and content

Abstract

A new method for the synthesis of enediynes is described based on stannylcupration of acetylene and certain activated alkynes, in situ reaction with 1-halo-1-alkynes, iododestannylation, and Pd(0)-catalyzed coupling with terminal alkynes.

A new method for the synthesis of enediynes is described based on stannylcupration of acetylene and certain activated alkynes, in situ reaction with 1-halo-1-alkynes to provide stannyl enynes (45–75%), iododestannylation, and coupling with terminal alkynes.

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Presented at the 201st National Meeting of the American Chemical Society, Atlanta, GA, April 14-19, 1991; paper ORGN 42.

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