A novel approach to the synthesis of enediynes☆
A new method for the synthesis of enediynes is described based on stannylcupration of acetylene and certain activated alkynes, in situ reaction with 1-halo-1-alkynes to provide stannyl enynes (45–75%), iododestannylation, and coupling with terminal alkynes.
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Presented at the 201st National Meeting of the American Chemical Society, Atlanta, GA, April 14-19, 1991; paper ORGN 42.
Copyright © 1991 Published by Elsevier Ltd.