Elsevier

Survey of Ophthalmology

Volume 36, Issue 1, July–August 1991, Pages 28-46
Survey of Ophthalmology

Therapeutic review
Botulinum A toxin (Oculinum®) in ophthalmology

https://doi.org/10.1016/0039-6257(91)90207-VGet rights and content

Abstract

Botulinum A toxin has been used to treat strabismus and a variety of spasmodic neuromuscular diseases. Botulinum toxin treatment of strabismus is not as definitive and stable as the traditional surgical approach, but it has been found most useful in postoperative overcorrection, small deviations, sensory deviations, and acute sixth nerve palsy. This toxin has been effective in the treatment of essential blepharospasm and hemifacial spasm, for which it produces temporary relief of symptoms. In addition, this treatment has been applied to lower lid entropion, myokymia, aberrant regeneration of the seventh nerve, lid retraction, corneal exposure, nystagmus, spasmodic torticollis, and adductor spastic dysphonia.

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    Supported in part by the Hippocrates Foundation from Tokyo Medical College and an Unrestricted Research Grant from Research to Prevent Blindness, Inc.

    1

    Dr. Osako is currently working in the Department of Ophthalmology, Tokyo Medical College Hospital (6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo, Japan 160).

    2

    Dr. Keltner is a consultant to Allergan Pharmaceuticals.

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