Elsevier

Metabolism

Volume 24, Issue 4, April 1975, Pages 473-480
Metabolism

Uric acid kinetic studies in the immediate post-myocardial-infarction period

https://doi.org/10.1016/0026-0495(75)90072-4Get rights and content

Abstract

The etiology of hyperuricemia following myocardial infarction was investigated by uric acid kinetic studies carried out on seven male patients following myocardial infarction and on two control subjects. The patients selected had uncomplicated myocardial infarction and were maintained on a low-purine diet. Measurements of uric acid pool size and turnover rates using 2-C14 uric acid were made, commencing on days 2–5 following myocardial infarction. Initial concentration of serum uric acid ranged from 2.9 to 9.8 mg100 ml. Uric acid pool size was elevated in six of seven patients. Five had a pool size of from 36.9 to 79.6 mg/kg, while the single gouty subject demonstrated 104 mg/kg compared with 12.6 and 16.8 mg/kg for the control subjects. Turnover rates were also increased, ranging from 1036 to 2772 mg/day (controls, 612 and 872 mg/day). Twenty-four-hour urine uric acid excretions ranged from 358 to 623 mg24 hr. Serum lactic acid concentration was normal (1.03 ± 0.17 μM/ml), and endogenous creatinine clearance in all cases was 77.9 ml/min or greater. These data suggest that following myocardial infarction there is an expansion of the uric acid pool with an increased uric acid turnover rate. Only the patient with a previous history of gout had uric acid excretion outside the normal range.

References (45)

  • TH Steele et al.

    The renal mechanism for urate homeostasis in normal man

    Am J Med

    (1967)
  • VA Kurien et al.

    Serum-free-fatty-acids after acute myocardial infarction and cerebrovascular occlusion

    Lancet

    (1966)
  • C Valori et al.

    Urinary excretion of free noradrenalin and adrenalin following acute myocardial infarction

    Lancet

    (1967)
  • WN Kelley et al.

    Current concepts in the pathogenesis of hyperuricemia

    Metabolism

    (1973)
  • MM Gertler et al.

    Serum uric acid in relation to age and physique in health and in coronary heart disease

    Ann Intern Med

    (1951)
  • PM Kohn et al.

    Hyperuricemia: Relationship to hypercholesterolemia and acute myocardial infarction

    JAMA

    (1959)
  • M Spring et al.

    Hyperuricemia and hyperglycemia in acute myocardial infarction

    Circulation

    (1960)
  • AP Hall

    Correlations among hyperuricemia, hypercholesterolemia, coronary disease and hypertension

    Arthritis Rheum

    (1965)
  • E Ask-Upmark et al.

    Coronary infarction and gout

    Acta Med Scand

    (1950)
  • JN Harris-Jones

    Hyperuricemia and essential hypercholesterolemia

    Lancet

    (1957)
  • DB Berkowitz

    Blood lipid and uric acid interrelationships

    JAMA

    (1964)
  • TG Benedek

    Correlations of serum uric acid and lipid concentrations in normal, gouty, and atherosclerotic men

    Ann Intern Med

    (1967)
  • Cited by (0)

    Supported by grants from the Medical Research Council, Nos. MA-3331 and MT-3238, and by the Canadian Arthritis and Rheumatism Society.

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