Hyperinsulinemia and insulin resistance in genetically obese rats☆
References (34)
Spontaneous biabetes and/or obesity in laboratory rodents
Advances Metab. Dis.
(1968)- et al.
The islets of Langerhans in rats with hypothalamic obesity
Lancet
(1963) Lipogenesis from glucose and pyruvate in fat cells from genetically obese rats
J. Lipid Res.
(1968)Colorimetric ultramicro method for determination of free fatty acids
J. Lipid Res.
(1965)- et al.
Plasma triglycerides in genetically obese rats
Metabolism
(1969) - et al.
Obesity and insulin resistance in the obesehyperglycemic mouse (obob)
Metabolism
(1969) Some effects of caloric restriction and deprivation on the obese hyperlipemic rat
J. Nutr.
(1967)- et al.
Mobilization of fatty acids in genetically obese rats
J. Lipid Res.
(1970) - et al.
Measurements of insulin in pancreas and serum of mice with spontaneous (obese and New Zealand obese) and induced (goldthioglucose) obesity and hyperglycemia with considerations on the pathogenesis of the spontaneous syndrome
Diabetologia
(1967) - et al.
Studies with the mutation, diabetes, in the mouse
Diabetologia
(1967)
Genetically transmitted obesity in rodents
Physiol. Rev.
Serum insulin levels in spontaneously diabetic mice of the KK strain
Physiologist
Studies on experimental diabetes in the Wellesley hybrid mouse. II. Insulin levels and response of peripheral tissues
Diabetologia
Plasma glucose, non-esterified fatty acids and insulin concentrations in hypothalamic hyperphagic rats
Biochem. J.
The mutation, diabetes, in the mouse
Studies in a diabetic (KK) strain of mice
Diabetologia
Development of the obese-hyperglycemic syndrome
Diabetologia
Cited by (58)
Effects of visceral fat resection and gastric banding in an obese diabetic rat model
2012, SurgeryCitation Excerpt :The ZDF rat is a commonly used animal model of type 2 diabetes because many characteristic features of this model are common with those of human obese type 2 diabetes. This rat model is characterized by marked hyperinsulinemia and insulin resistance.24,25 The animals were acclimatized to the local facilities for 14 days before operation.
Prevention of obesity-linked renal disease: Age-dependent effects of dietary food restriction
2002, Kidney InternationalProtective effects of a soy diet in preventing obesity-linked renal disease
2002, Kidney InternationalCardiac and behavioral responses of long-term obese and lean Zucker rats to emotional stress
1995, Physiology and BehaviorZucker obese rats: defect in brain histamine control of feeding
1992, Brain Research
- ☆
Supported in part by NIH Grants AM-9897, AM-5166, AM-15165, and RR-00425.
- 1
David A. York, Ph.D.: Research Fellow in Endocrinology, UCLA School of Medicine, Los Angeles, Calif., and Harbor General Hospital, Torrance, Calif.; presently Lecturer, Department of Physiology and Biochemistry, Southampton University, Southampton, England.
- 2
Jurgen Steinke, M.D.: Assistant Professor of Medicine, Harvard Medical School, and Elliot P. Joslin Research Laboratories, Boston, Mass.
- 3
George A. Bray, M.D.: Associate Professor of Medicine, UCLA School of Medicine, Los Angeles, Calif., and Harbor General Hospital, Torrance, Calif.