Elsevier

Metabolism

Volume 21, Issue 4, April 1972, Pages 277-284
Metabolism

Hyperinsulinemia and insulin resistance in genetically obese rats

https://doi.org/10.1016/0026-0495(72)90070-4Get rights and content

Abstract

Serum immunoreactive insulin levels (IRI) and insulin sensitivity were studied in lean, genetically obese “fatty” rats, and rats that became obese following hypothalamic lesions. Serum IRI was increased in obese “fatty” rats at 6 wk, 4 mo, and 11 mo of age. Similar increases were observed in hypothalamic lesioned (HTL) obese rats. Histologic changes in the appearance of islet tissue were described. Insulin sensitivity was studied in both “fatty” and HTL rats after a 19-hr fast. Genetic, but not regulatory, obesity was accompanied by insulin resistance. Possible reasons for this difference are discussed.

References (34)

  • G.A. Bray et al.

    Genetically transmitted obesity in rodents

    Physiol. Rev.

    (1971)
  • J.H. Birnie et al.

    Serum insulin levels in spontaneously diabetic mice of the KK strain

    Physiologist

    (1967)
  • G.F. Cahill et al.

    Studies on experimental diabetes in the Wellesley hybrid mouse. II. Insulin levels and response of peripheral tissues

    Diabetologia

    (1967)
  • C.N. Hales et al.

    Plasma glucose, non-esterified fatty acids and insulin concentrations in hypothalamic hyperphagic rats

    Biochem. J.

    (1964)
  • D.L. Coleman et al.

    The mutation, diabetes, in the mouse

  • M. Nakamura et al.

    Studies in a diabetic (KK) strain of mice

    Diabetologia

    (1967)
  • S. Westman

    Development of the obese-hyperglycemic syndrome

    Diabetologia

    (1968)
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