Elsevier

Life Sciences

Volume 20, Issue 2, 15 January 1977, Pages 337-341
Life Sciences

Drugs and drug metabolites as environmental contaminants: Chlorophenoxyisobutyrate and salicylic acid in sewage water effluent

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Abstract

Chlorophenoxyisobutyrate (CPIB) and salicylic acid, the metabolites of clofibrate and aspirin, were quantitated by gas chromatography-mass spectrometry in the effluent of a sewage disposal plant in Kansas City, Missouri. The average daily output of CPIB was 2.1 (0.76–2.92) kg and salicylic acid 8.64 (0.55–28.69) kg over a 10 month period. Approximately one-half of the clofibrate consumed in this area is discharged into the Missouri River.

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