Particle size and size distribution of poly(butyl-2-cyanoacrylate) nanoparticles: I. Influence of physicochemical factors

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Abstract

Polyalkylcyanoacrylate nanoparticles can be produced by a dispersion polymerization process carried out in an aqueous phase at low pH. The influence of physicochemical factors such as temperature, pH of solution, monomer concentration, type and concentration of electrolyte, stirring rate and acidifying agent on the resultant particle size, and size distribution of poly(butyl-2-cyanoacrylate) nanoparticles was investigated. Particle size characterization was performed by photon correlation spectroscopy (PCS) and scanning electron microscopy (SEM). The pH of the solution during polymerization and to a lesser degree the initial monomer concentration were shown to be important factors in controlling the particle size of the nanoparticles in the range of 100–200 nm (average diameter). Within the limits of the experiments a change in the remaining factors did not alter the particle size significantly.

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