Elsevier

Experimental Neurology

Volume 97, Issue 2, August 1987, Pages 365-374
Experimental Neurology

Extent of fiber regeneration after peripheral nerve repair: Silicone splint vs. suture, gap repair vs. graft

https://doi.org/10.1016/0014-4886(87)90096-3Get rights and content

Abstract

The degree of regeneration in surgically repaired sciatic nerves in rats was measured using a simple new electrophysiologic method: comparison of the size of nerve responses evoked by stimulation distal and proximal to the anastomosis. Five different repair procedures were evaluated. After simple end-to-end suture anastomosis, about 40% of the severed parent fibers regenerated past the suture line. The result was substantially improved when the anastomosis was covered with a newly designed thin-wall silicone sheath which incorporated a narrow longitudinal slit. The presence of suture material at the point of anastomosis had no effect. Finally, regeneration across a 5-mm gap ensheathed in silicone (67%) was better than regeneration through a 5-mm autograft (45%).

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    1

    Supported by grants from the Israel Ministry of Health and the Israel Academy of Arts and Sciences to M.D.

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