Comparison of the ultrastructural myopathy induced by anticholinesterase agents at the end plates of rat soleus and extensor muscles
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2008, Handbook of Clinical NeurologyCitation Excerpt :Apart from paraoxon, other OP compounds such as soman (Dekleva et al., 1989), DFP (Ariëns et al., 1969; Gupta et al., 1986), and carbamate AChE inhibitors such as pyridostigmine (Hudson and Foster, 1984; Hudson et al., 1985) and neostigmine (de Clermont, 1854) have been reported to induce a similar myopathy in rats. Meshul et al. (1985) described the ultrastructural lesions in rat neuromuscular junctions after acute sarin or soman, or chronic pyridostigmine treatment. They noted early swelling of membrane‐bound organelles (mitochondria, sarcoplasmic reticulum, nuclear envelope) followed by dissolution of Z‐disks and a pronounced expansion of nuclear chromatin.
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Dr. Meshul's current address is Office of Regeneration Research Programs, VA Medical Center, P.O. Box 1034, Portland, OR 97207.
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This work was supported by U.S. Army Medical Research and Development Comand contract 17-81-C-1279.