Elsevier

Experimental Neurology

Volume 25, Issue 4, September 1969, Pages 494-508
Experimental Neurology

Transport of protein in goldfish optic nerve during regeneration

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Abstract

After the optic tract was cut in goldfish, transport of protein in the intact optic nerve segment attached to the eye was increased. The rate of “slow” transport, which is normally 0.4 mm per day, was increased about three-fold. The increase began between 6 and 8 days after the cut, and was maximal about 212 weeks after the cut, just prior to the time that recovery of vision occurred. The rate remained elevated for several weeks after the optic fibers had connected with the tectum. The rate of “fast” transport, which is normally about 40 mm per day, was found to be approximately twice normal about 2 weeks after reconnection had occurred.

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  • Cited by (0)

    1

    We are indebted to Dr. Paul Weiss for his interest, and for the use of some of his facilities and equipment. We acknowledge gratefully the technical assistance of Miss Roberta Alpert, Miss Jacqueline Rausch, Mr. Sam Briseno, and Mr. Michael Gomez. We are also grateful to Mr. T. O'Mara for his dependable service in supplying the fish. This work was supported by NSF Grant GB-4208 and PHS Grants NB-08156 and NB-09015 from NINDS to Dr. Grafstein, and PHS Grant NB-07348 from NINDS to Dr. Weiss. Dr. Grafstein's present address is Department of Physiology, Cornell University Medical College New York, New York 10021

    2

    that of Dr. Murray is Department of Anatomy, University of Chicago, Chicago, Illinois 60637.

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