Original articleInteraction of liposomes with Kupffer cells in vitro☆
References (41)
- et al.
Biochim biophys acta
(1981) - et al.
Biochim biophys acta
(1978) - et al.
Biochim biophys acta
(1979) - et al.
Biochim biophys acta
(1980) - et al.
Biochim biophys acta
(1980) - et al.
Exp cell res
(1976) - et al.
Biochim biophys acta
(1981) - et al.
J biol chem
(1951) - et al.
J biol chem
(1960)
Exp cell res
J ultrastruct res
Cell
Exp cell res
Biochem pharmacol
FEBS lett
Exp cell res
Eur j biochem
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These investigations were carried out under the auspices of the Netherlands Foundation for Medical Research (FUNGO) with financial support from the Netherlands Organization for the Advancement of Pure Research (ZWO).