Effects of anticancer agents on the respiration of isolated mitochondria and tumor cells

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Abstract

A number of anticancer agents of high efficiency and yet considerable toxicity, interact with the bioenergetics and ion transport of not only the target tumor cells, but those of the host organs as well. The possibility that there is a generalized site of toxicity of such agents with the host organ, particularly the heart and liver, has encouraged us to make a more detailed study of the site of action of respiratory inhibition by a variety of anticancer drugs selected for this purpose.

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The work reported in this paper was supported by Contract NIH-71-2188, from the Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Education and Welfare and by grant 12-513-73 of Instituto Nacional de Prevision.

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