Full paperNaturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: Evidence for the role of cell death genes☆
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2021, Acta HistochemicaCitation Excerpt :In SH-SY5Y cell line, FIP induced apoptosis through ROS overproduction and oxidative stress induction (Ki et al., 2012). Apoptosis is a cellular self-destruction process that needs the expression of particular genes and regulation of many proteins (Oppenheim et al., 1990), including B cell lymphoma 2 (BCL-2) family proteins and caspases (Khalil et al., 2015). BCL-2 is a family of proteins containing pro-apoptotic (BAX) and anti-apoptotic (BCL-2) proteins, whose interaction determines the occurrence of cell death (Korsmeyer, 1999).
Protein synthesis inhibition promotes nitric oxide generation and activation of CGKII-dependent downstream signaling pathways in the retina
2020, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :Additionally, in a model of kainate-induced seizures, neuronal cell death was strongly dependent on protein synthesis and CHX completely prevented the kainate effect [43]. Furthermore, Oppenheim and colleagues [11] demonstrated, using an in vivo model of naturally occurring neuronal cell death, that CHX could also be a protective player in developing avian neurons. We have previously demonstrated that NO produced from exogenous source (NO donor SNAP) or endogenous source (L-Arg treatment) acts as a protective agent for cultured retinal neurons [21,23].
Consequences of brain-derived neurotrophic factor withdrawal in CNS neurons and implications in disease
2017, Neurobiology of DiseaseAxonal Degeneration Is Regulated by a Transcriptional Program that Coordinates Expression of Pro- and Anti-degenerative Factors
2016, NeuronCitation Excerpt :Loss of trophic signaling was found to elicit transcriptional programs that govern neuronal death as well as axonal degeneration. Early studies using the developing chick embryo demonstrated that active transcription is required for cell death induced by ablation of the peripheral targets (Oppenheim et al., 1990). In later studies, the transcription factor c-Jun, members of the p53 family, and the transcriptionally induced BH3-only proteins Hrk and Bim were identified as key regulators of the apoptosis of sympathetic and dorsal root ganglion (DRG) neurons during development (Aloyz et al., 1998; Ham et al., 1995; Imaizumi et al., 1997; Putcha et al., 2001).
Neurotrophin roles in retinal ganglion cell survival: Lessons from rat glaucoma models
2009, Experimental Eye Research
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These studies were supported by NIH Grant NS20402.