Morphogenetic interactions in the development of the mouse thymus gland☆
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2016, Encyclopedia of ImmunobiologyEvolution of thymus organogenesis
2013, Developmental and Comparative ImmunologyCitation Excerpt :But these data suggest that in primitive vertebrates, novel transcriptional regulation of FOXN1 is quickly expanding and an evolutionarily novel genetic network of thymus is establishing. Interactions between NCC-derived mesenchyme and thymic epithelial cells are essential in the organogenesis of embryonic thymus (Auerbach, 1960; Jenkinson et al., 2003; Bockman and Kirby, 1984; Griffith et al., 2009). The neural crest seems to co-evolve with the thymus in lampreys.
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2010, Medecine et LongeviteEvidence for an early role for BMP4 signaling in thymus and parathyroid morphogenesis
2010, Developmental BiologyIncreased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos
2009, Developmental BiologyCitation Excerpt :These results suggest that delayed separation from pharyngeal endoderm likely contributes to the ectopic position of Pax3Sp/Sp thymus lobes. The fetal thymus rudiment is encompassed by a NC-derived mesenchymal capsule that provides essential signals to the developing thymic epithelial compartment (Auerbach, 1960; Foster et al., 2008; Jenkinson et al., 2007). Thymic sections were stained with anti-PDGFRα to detect the NC-derived mesenchymal capsule surrounding the cytokeratin positive thymus epithelial rudiment in E12.5 Pax3Sp/Sp and Pax3+/+ littermates.
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Supported in part by research grant C-3985 from the National Institutes of Health, and by an institutional grant from the American Cancer Society.
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With the technical assistance of William D. Ball.