Analysis of conjugated and unconjugated bile acids in serum and jejunal fluid of normal subjects
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Analysis of the interplay of physiological response to food intake and drug properties in food-drug interactions
2023, Drug Metabolism and PharmacokineticsCritical aspects involved in lipid dispersion and digestion: Emphasis on in vitro models and factors influencing lipolysis of oral lipid based formulations
2023, Advances in Colloid and Interface ScienceDevelopment of self-microemulsifying tablets containing dutasteride for enhanced dissolution and pharmacokinetic profile
2022, International Journal of PharmaceuticsPrediction of negative food effect induced by bile micelle binding on oral absorption of hydrophilic cationic drugs
2020, European Journal of Pharmaceutical SciencesCitation Excerpt :The oral absorption of a drug is determined by the solubility, dissolution rate, and permeability of the drug in the gastrointestinal tract (Oh et al., 1993). Food intake changes various gastrointestinal physiological conditions, such as the stomach pH (Dressman, 1986), intestinal pH (Vertzoni et al., 2019), gastric emptying time (Davis et al., 1986), hepatic blood flow (Olanoff et al., 1986), and bile micelle concentration (Tangerman et al., 1986). In particular, the concentration of bile micelles in the small intestine is markedly increased after food ingestion.
Variations in gastrointestinal lipases, pH and bile acid levels with food intake, age and diseases: Possible impact on oral lipid-based drug delivery systems
2019, Advanced Drug Delivery ReviewsCitation Excerpt :The intestinal BA concentrations has been reported to be highly variable during meal digestion and found between 0.5 mM [135] and 37 mM [47]. Nevertheless, the postprandial BA levels recorded after 30 to 60 min, which corresponds to the gallblader emptying [134,136], are often close to 15 mM [47,135,137–139], as recently reported by Humbert et al. (14.8 ± 12.7 mM) [63]. After gallbladder emptying, the duodenal concentration of BA decreases and levels off around 3–4 mM after 120 min (Fig. 5C).
Postprandial bile acid levels in intestine and plasma reveal altered biliary circulation in chronic pancreatitis patients
2018, Journal of Lipid ResearchCitation Excerpt :Furthermore, the peak in duodenal concentration of BAs observed 30 min after meal ingestion was typical of normal gallbladder emptying (27, 28). While highly variable intestinal concentrations of BAs under fed conditions have been reported in the literature, ranging from 0.5 (29) to 37 mM (30), there is an agreement for duodenal concentrations recorded 30–60 min after a meal and following gallbladder emptying: 14.5 ± 8.8 mM (mean ± SD, n = 5) reported by Hernell, Staggers, and Carey (30), 14.7 ± 8.0 mM (mean ± SD, n = 16) by Tangerman, Schaik, and van der Hoek (31), 15.8 ± 5.6 mM (mean ± SD, n = 5) by Ladas et al. (29), 16.2 ± 1.5 mM (mean ± SE, n = 13) by Rautureau, Bisalli, and Rambaud (32), 14.5 ± 9.4 (mean ± SD, n = 12) by Fausa (33), and 8.3 mM (normal meal) to 11.9 mM (high-fat meal) reported by Clarysse et al. (28). The mean duodenal BA concentration measured presently after 30 min in HVs (14.8 ± 12.7 mM, n = 6; Fig. 2A) was therefore consistent with previous data.